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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
multidrug resistance transporter
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "multidrug resistance transporter" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P81118
Synonyms: ABC30 antibody;
abcC2 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 2 antibody;
ATP binding cassette subfamily C member 2 antibody;
ATP-binding cassette sub-family C member 2 antibody;
Canalicular multidrug resistance protein antibody;
Canalicular multispecific organic anion transporter 1 antibody;
CMOAT antibody;
CMOAT1 antibody;
cMRP antibody;
DJS antibody;
KIAA1010 antibody;
MRP 2 antibody;
MRP2_HUMAN antibody;
multidrug resistance associated protein 2 antibody;
multidrug resistance-associated protein 2 antibody;
1
1 Cited Publications
Cat. No.: HY-P703175
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. MDR1; Phospholipid transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; multidrug resistance Protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
Cat. No.: HY-D0180
CAS No.: 17455-13-9
Synonyms: 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane
Category:
Alkaloids Leguminosae Other Diseases Plants Disease Research Fields Indigofera Indole Alkaloids
Target:
Target:
Research Areas:
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .
Cat. No.: HY-132189
CAS No.: 197509-46-9
Target:
Research Areas:
Laniquidar is a non-competitive P-gp inhibitor with an IC50 of 0.51 μM. Laniquidar binds to the P-gp transporter with high affinity and exhibits low activity as a substrate. Laniquidar is applicable to epilepsy-related research .
Cat. No.: HY-162753
CAS No.: 2351940-23-1
Target:
Research Areas:
ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer .
Cat. No.: HY-N0406
CAS No.: 861691-37-4
Category:
other families Flavonoids Plants Disease Research Fields Inflammation/Immunology Isoflavones
Target:
Cat. No.: HY-120950
CAS No.: 125741-64-2
Target:
Research Areas:
S-Farnesyl-L-cysteine methyl ester is a multidrug resistance transporter activator. S-Farnesyl-L-cysteine methyl ester acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding .
Cat. No.: HY-155152
CAS No.: 3052839-42-3
Target:
Research Areas:
P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin (HY-15142A) in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells .
Cat. No.: HY-N0406R
CAS No.: 861691-37-4
Category:
Target:
Cat. No.: HY-144393
CAS No.: 2764596-06-5
P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel) .
Cat. No.: HY-P810860
Synonyms: CMOAT, CMOAT1, CMRP, MRP2, ABCC2, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, multidrug resistance-associated protein 2
Cat. No.: HY-P703108
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABCC2; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2; Prev. CMOAT; multidrug resistance-Associated Protein 2; CMRP; Canalicular multidrug resistance Protein; MRP2; CMOAT1; Canalicular Multispecific Organic Anion transporter 1; ABC30; DJS; ATP Bi
Species:
Human
Source:
HEK293
Cat. No.: HY-P703109
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ABCC2; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2; Prev. CMOAT; multidrug resistance-Associated Protein 2; CMRP; Canalicular multidrug resistance Protein; MRP2; CMOAT1; Canalicular Multispecific Organic Anion transporter 1; ABC30; DJS; ATP Bi
Species:
Human
Source:
HEK293
Cat. No.: HY-13774
CAS No.: 908859-10-9
Target:
Research Areas:
WK-X-34 is a low-toxicity, highly effective multidrug resistance reversal agent. By potently inhibiting the transport functions of P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP), WK-X-34 significantly increases the intracellular accumulation of anticancer drugs and radiotracers in drug-resistant cells. WK-X-34 exerts no significant effect on MRP transporters. WK-X-34 not only restores the chemosensitivity of multidrug-resistant ovarian cancer cells, but also significantly enhances the uptake of 99mTc-Sestamibi in P-gp-positive xenograft tumors, brain and intestinal tissues. WK-X-34 exhibits extremely low toxicity and favorable safety profiles both in vitro and in mice (at doses up to 50 mg/kg), and can be used for research on overcoming multidrug resistance in ovarian cancer .
Cat. No.: HY-P703279
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABCC5; Multi-Specific Organic Anion transporter C; ATP Binding Cassette Subfamily C Member 5; multidrug resistance-Associated Protein 5; MOAT-C; PABC11; MRP5; Canalicular Multispecific Organic Anion transporter C; SMRP; ABCC5 Protein; EST277145; ABC33; AT
Species:
Human
Source:
HEK293
Cat. No.: HY-101453R
CAS No.: 315702-40-0
Target:
Research Areas:
Ceefourin 1 (Standard) is the analytical standard of Ceefourin 1 (HY-101453). This product is intended for research and analytical applications. Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .
Cat. No.: HY-179683
Target:
Research Areas:
MRP1-IN-2 (Compound 21) is a selective MRP1 inhibitor with a relatively weak inhibitory effect on P-gp. MRP1-IN-2 exhibits a strong accumulation effect of calcein, with its EC50 value being 177 nM. MRP1-IN-2 enhances the activity of Doxorubicin (HY-15142A) on drug-resistant cells. MRP1-IN-2 can be used for the study of multidrug-resistant cancers .
Cat. No.: HY-P703174
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. MDR1; Phospholipid transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; multidrug resistance Protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
