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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
murine COX-2
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "murine COX-2" in MCE Product Catalog:
2
Target:
Potassium Channel Free Radical Scavengers ERK STAT NF-κB COX Interleukin Related Reactive Oxygen Species (ROS)
Research Areas:
Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers .
2
2 Cited Publications
Cat. No.: HY-W010983
CAS No.: 170569-86-5
Research Areas:
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .
Cat. No.: HY-N2106
CAS No.: 67909-49-3
Category:
Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids
Target:
Synonyms: (-)-Resolvin E2
Research Areas:
Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E2, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors . Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions .
Cat. No.: HY-161612
CAS No.: 149092-45-5
Target:
Research Areas:
Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases .
Cat. No.: HY-N8712
CAS No.: 43053-62-9
Category:
Monophenols Other Diseases Coumarins Phenols Pelargonium hortorum Phenylpropanoids Plants Disease Research Fields Geraniaceae
Target:
Cat. No.: HY-170585
CAS No.: 3064260-49-4
Research Areas:
COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397) .
Cat. No.: HY-N2106R
CAS No.: 67909-49-3
Cat. No.: HY-W010983R
CAS No.: 170569-86-5
Target:
Research Areas:
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .
Cat. No.: HY-B1114R
CAS No.: 33342-05-1
Synonyms: AR-DF 26 (Standard)
Research Areas:
Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers .
Cat. No.: HY-B1114S
Synonyms: AR-DF 26-d6
Target:
Isotope-Labeled Compounds Potassium Channel Free Radical Scavengers ERK STAT NF-κB COX Interleukin Related Reactive Oxygen Species (ROS)
Research Areas:
Gliquidone-d6 (AR-DF 26-d6) is the deuterated-labeled Gliquidone (HY-B1114). Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers .
Cat. No.: HY-B1114A
CAS No.: 62783-47-5
Synonyms: AR-DF 26 sodium
Target:
Potassium Channel Free Radical Scavengers ERK STAT NF-κB COX Interleukin Related Reactive Oxygen Species (ROS)
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Gliquidone sodium (AR-DF 26 sodium) can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone sodium significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone sodium can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone sodium also exhibits good anticancer activity in lung carcinoma cells. Gliquidone sodium has antioxidant property. Gliquidone sodium can be studied in research for type 2 diabetes and cancers .
Cat. No.: HY-126453
CAS No.: 1632301-78-0
VU0487836 is a selective cyclooxygenase-1 (COX-1) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 serves as a prototype for the development of radiological imaging agents targeting COX-1 for ovarian cancer. VU0487836 is applicable to relevant research on ovarian cancer .
Cat. No.: HY-187563
Target:
Research Areas:
RNP-11 is a selective COX-2 inhibitor with an IC50 of 42.85 μg/mL against human COX-2, and also acts as a bactericide and anti-inflammatory agent. RNP-11 inhibits the production of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β, disrupts bacterial cell membranes and induces bacterial cell death. RNP-11 exhibits activity against strains of Staphylococcus and Enterococcus, including Methicillin (HY-121544)-resistant Staphylococcus aureus and Vancomycin (HY-B0671)-resistant Enterococcus faecium. RNP-11 reduces the load of Staphylococcus aureus, exerting dual effects of pathogen clearance and inflammatory response alleviation in a mouse skin infection model,. RNP-11 can be used in research related to infections caused by Staphylococcus, Staphylococcus aureus and Enterococcus faecium .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
