43053-62-9
43053-62-9
Chemical Structure
Umckalin
- CAS No.: 43053-62-9
- Formula:C11H10O5
- Molecular Weight:222.19
IUPAC Name: 7-hydroxy-5,6-dimethoxy-2H-chromen-2-one
InChIKey: DVBPETFXQYSHLJ-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(OC)C(OC)=C(O)C=C2O1
Biological Activity: Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases[1][2].
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Umckalin | Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases. | |||||||||||||||||||||
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Umckalin (Standard) | ≥98% | Umckalin (Standard) is the analytical standard of Umckalin (HY-N8712). Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases. | ||||||||||||||||||||
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References
- [1]. Oh S-Y, et al. Anti-Inflammatory Potential of Umckalin Through the Inhibition of iNOS, COX-2, Pro-Inflammatory Cytokines, and MAPK Signaling in LPS-Stimulated RAW 264.7 Cells. Future Pharmacology. 2025; 5(1):6.
- [2]. Oh S-Y, et al. Umckalin Promotes Melanogenesis in B16F10 Cells Through the Activation of Wnt/β-Catenin and MAPK Signaling Pathways. Applied Biosciences. 2025; 4(2):20.
