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neutral endopeptidase-24.11

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neprilysin (1) Prolyl Endopeptidase (PREP) (2) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Dopamine Receptor (1) Drug Intermediate (1) Endothelin-Converting Enzyme (ECE) (1) Opioid Receptor (1)
By Research Areas:	Cardiovascular Disease (4) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

5

Inhibitors & Agonists

8

Recombinant Proteins

4

Antibodies

Targets Recommended: Neprilysin Calpain Legumain Prolyl Endopeptidase (PREP)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

RB 101	Prolyl Endopeptidase (PREP) Aminopeptidase Opioid Receptor Dopamine Receptor Drug Intermediate	Neurological Disease Metabolic Disease Inflammation/Immunology
RB 101 is a blood-brain barrier-crossing prodrug as well as aminopeptidase N and **neutral endopeptidase-24.11 inhibitor. RB 101 blocks enkephalin breakdown, elevates extracellular enkephalin levels and activate δ-opioid receptor and dopamine D1 receptor**. RB 101 can be used for the research of pain, depressive syndromes, and diabetic neuropathy .

CGS35066	Endothelin-Converting Enzyme (ECE)	Cardiovascular Disease
CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC₅₀ values of 22 nM and 2.3 μM, respectively .

CGS 24592	Prolyl Endopeptidase (PREP)	Cardiovascular Disease
CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC₅₀ value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure .

CGS25155	Neprilysin	Cardiovascular Disease
CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC₅₀ of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research .

CGS 35601	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC₅₀s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .

Species:	Human (4) Rhesus Macaque (1) Mouse (1) Rat (1) Cynomolgus (1)
Tag:	His (5) Tag Free (2) Fc (1)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source	Image

	MME Protein, Cynomolgus (HEK293, His) Neprilysin; Atriopeptidase; Enkephalinase; neutral endopeptidase 24.11; Skin fibroblast elastase; MME;	Cynomolgus	HEK293
	MME Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MME protein, expressed by HEK293, with N-His tag.

	MME Protein, Human (HEK293, N-His) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293, N-His) is the recombinant human-derived MME protein, expressed by HEK293 , with N-His labeled tag.

	MME/Neprilysin Protein, Rat (HEK293, His) Neprilysin; CALLA; NEP; SFE; CD10; MME	Rat	HEK293
	Neprilysin/CD10 protein has a specificity similar to thermolysin and mainly acts on polypeptides of up to 30 amino acids. It plays a crucial role in degrading opioid peptides, including Met-enkephalin and Leu-enkephalin, by cleaving the Gly-Phe bond. MME/Neprilysin Protein, Rat (HEK293, His) is the recombinant rat-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag.

	MME/Neprilysin Protein, Rhesus Macaque (HEK293, His) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME	Rhesus Macaque	HEK293
	MME is a cell-surface peptidase member of the M13 family of zinc peptidases, which also includes endothelin converting enzymes (ECE-1 and ECE-2), KELL and PEX. MME cleaves peptide bonds on the amino side of hydrophobic amino acids and is the key enzyme in processing of a variety of physiologically active peptides, such as GRP, neurotensin (NT), and vasoactive intestinal peptide (VIP). MME is downregulated in nearly 50% of primary and metastatic prostate cancers. MME/Neprilysin Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag.

	MME Protein, Human (HEK293, Tag Free) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293) is the recombinant human-derived MME protein, expressed by HEK293 , with tag free.

	MME Protein, Human (HEK293) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293) is the recombinant human-derived MME protein, expressed by HEK293 , with tag free.

	MME Protein, Human (HEK293, Fc) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293, Fc) is the recombinant human-derived MME protein, expressed by HEK293 , with N-hFc labeled tag.

	MME Protein, Mouse (HEK293, His) Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Mouse	HEK293
	MME Protein, with thermolysin-like specificity, crucially degrades opioid peptides like Met- and Leu-enkephalins, cleaving a Gly-Phe bond.It also catalyzes the cleavage of bradykinin, substance P, neurotensin peptides, angiotensin-1, angiotensin-2, and angiotensin 1-9.Involved in atrial natriuretic factor (ANF) degradation, MME exhibits UV-inducible elastase activity towards skin preelastic and elastic fibers.MME Protein, Mouse (HEK293, His) is the recombinant mouse-derived MME protein, expressed by HEK293 , with N-His labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (3) Mouse (2)
Application:	IHC-P (4) ICC/IF (3) IP (2) WB (3) ELISA (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

	CD10 Antibody (YA6069) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; neutral endopeptidase 24.11; NEP; neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD10 Antibody (YA6069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

	CD10 Antibody (YA5352) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; neutral endopeptidase 24.11; NEP; neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	ICC/IF, IHC-P	Human, Mouse, Rat
	CD10 Antibody (YA5352) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

	CD10 Antibody (YA4772) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; neutral endopeptidase 24.11; NEP; neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10	WB, IHC-P, ICC/IF, ELISA	Human
	CD10 Antibody (YA4772) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

	CD10 Antibody (YA1313) CALLA, NEP,Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; neutral endopeptidase 24.11; NEP; neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, IP	Human, Rat
	CD10 Antibody (YA1313) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

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