Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
normal human dermal fibroblasts
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "normal human dermal fibroblasts" in MCE Product Catalog:
Category:
other families Metabolic Disease Plants Disease Research Fields Saccharides Cancer Monosaccharides
Target:
Cat. No.: HY-107425A
CAS No.: 1797406-72-4
Synonyms: MZP-42
Target:
Research Areas:
cis-MZ 1 (MZP-42) serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 can be used in colorectal cancer-related research .
Cat. No.: HY-P10233A
Cat. No.: HY-164826
CAS No.: 30881-23-3
Target:
Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis
Research Areas:
Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3 inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and PINK1/Parkin-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .
Cat. No.: HY-107425B
Purity: ≥99.0%
Target:
Research Areas:
cis-MZ 1 hydrate serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 hydrate can be used in colorectal cancer-related research .
Target:
Cat. No.: HY-181826
Target:
Research Areas:
IL-17-IN-6 is a IL-17 inhibitor with a pIC50 of 7.6 against human targets. IL-17-IN-6 binds to IL-17A and blocks downstream pro-inflammatory signaling pathways. IL-17-IN-6 inhibits the release of IL-6 from normal human skin fibroblasts stimulated by IL-17A and TNF. IL-17-IN-6 can be used for research on inflammatory and autoimmune diseases .
Cat. No.: HY-N16691
CAS No.: 24177-16-0
Target:
Cat. No.: HY-P11797
Target:
Research Areas:
Cat. No.: HY-184116
Research Areas:
A2AR/EGFR-IN-1 is a dual A2AR/EGFR inhibitor, with an IC50 of 0.037 μM against A2AR and an IC50 of 8.37 μM against EGFR. A2AR/EGFR-IN-1 induces cell cycle arrest at S and G2/M phases. A2AR/EGFR-IN-1 upregulates the expression of TP53, Caspase3 and Bax, downregulates the expression of Bcl2, and promotes cell Apoptosis. A2AR/EGFR-IN-1 restores colon crypt structure in an azoxymethane (HY-111375)-induced colorectal cancer model in vivo. A2AR/EGFR-IN-1 can be used for research related to colorectal cancer .
Cat. No.: HY-181827
Target:
Research Areas:
IL-17-IN-7 (Compound 23) is a IL-17 inhibitor with a pIC50 of 7.1 against IL-17A .
Cat. No.: HY-182285A
Target:
Research Areas:
5-HT7 modulator-1 hydrochloride is a selective 5-HT7 receptor antagonist with a Ki of 92 nM. 5-HT7 modulator-1 hydrochloride blocks 5-HT7 receptor signaling to reduce FOXM1, phosphorylated FOXM1, cyclin B1, and cdc25B levels. 5-HT7 modulator-1 hydrochloride acts as an antiproliferative, clonogenic inhibitor, and cell cycle inhibitor that induces G2/M arrest, reduces G0/G1 population. 5-HT7 modulator-1 hydrochloride can be used for the research of triple-negative breast cancer .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
