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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

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nuclear factor erythroid 2-related factor 2 (Nrf2)

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標的別:	Keap1-Nrf2 (7) AMPK (1) Apoptosis (1) Cholinesterase (ChE) (1) ERK (1) Ferroptosis (2) Interleukin Related (1) Phosphoglycerate Kinase (PGK) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
研究分野別:	Cancer (4) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

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Targets Recommended: Keap1-Nrf2 Orphan Nuclear Receptor NF-κB Nuclear Factor of activated T Cells (NFAT) Nuclear Hormone Receptor 4A/NR4A

製品番号	製品名	Target	研究分野	構造式

HY-100523

ML385 Maximum Cited Publications 576 Publications Verification	Keap1-Nrf2 Ferroptosis	Cancer
ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC₅₀ of 1.9 μM.

HY-101025

Nrf2-IN-1 5+ Cited Publications	Keap1-Nrf2	Cancer
Nrf2-IN-1 is an inhibitor of **nuclear factor-erythroid 2-related factor 2 (Nrf2)*. Nrf2-IN-1* is developed for the research of acute myeloid leukemia (AML) .

HY-147855

ACA-28 1 Publications Verification	ERK Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2	Cancer
ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma .

HY-152037

AChE/Nrf2 modulator 1	Cholinesterase (ChE) Keap1-Nrf2	Neurological Disease
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC₅₀ values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease .

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-177944

DC-PGKI	Phosphoglycerate Kinase (PGK) Keap1-Nrf2 Interleukin Related	Inflammation/Immunology
DC-PGKI is an orally active ATP-competitive PGK1 inhibitor(IC₅₀ = 0.16 Μm, K_d = 99.08 nM). DC-PGKI stabilizes PGK1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. DC-PGKI-mediated inhibition of PGK1 leads to the accumulation of *NRF2* (nuclear factor-erythroid factor 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and suppresses the LPS-induced expression of these genes. DC-PGKI can be used for the study of colitis .

HY-100523R

ML385 (Standard)	Keap1-Nrf2 Reference Standards Ferroptosis	Cancer
ML385 (Standard) is the analytical standard of ML385 (HY-100523). This product is intended for research and analytical applications. ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM.

製品番号	製品名	Target	研究分野

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

Host:	Mouse (1) Rabbit (7)
Reactivity:	Human (8) Rat (3) Mouse (5)
Application:	IHC-P (7) ICC/IF (6) IF-Tissue (1) IP (4) IHC-F (1) WB (8) ChIP (2) FC (2) ELISA (2)
Isotype:	IgG (8)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (6) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (4)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85818

	Nrf2 Antibody (YA5510) nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor, erythroid derived 2, like 2;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Nrf2 Antibody (YA5510) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Nrf2.

HY-P86092

	Nrf2 Antibody (YA5784) nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor, erythroid derived 2, like 2;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Nrf2 Antibody (YA5784) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nrf2.

HY-P81051

	Nrf2 Antibody(YA895) 5 Publications Verification NFE2L2; NRF2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2	WB, IHC-P, ICC/IF, IP, ChIP	Human, Mouse
	Nrf2 Antibody(YA895) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nrf2.

HY-P81051A

	Nrf2 Antibody(YA895)(PBS only) NFE2L2; NRF2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2	WB, IHC-P, ICC/IF, IP, ChIP	Human, Mouse
	Nrf2 Antibody(YA895) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nrf2.

HY-P86664

	Nrf2 Antibody (YA6356) NF2L2_HUMAN; nuclear factor erythroid 2-related factor 2; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; Nrf 2; nuclear factor, erythroid derived 2, like 2; NFE2L2; NRF2; NFE2 like bZIP transcription factor 2; HEBP1; IMDDHH;	WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF	Human, Mouse, Rat
	Nrf2 Antibody (YA6356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nrf2.

HY-P80471

	Phospho-Nrf2 (Ser40) Antibody (YA168) 2 Publications Verification NFE2L2; NRF2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2	WB, ICC/IF, IHC-P, FC, IP	Human
	Phospho-Nrf2 (Ser40) Antibody (YA168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Nrf2 (Ser40).

HY-P80841

	Phospho-Nrf2 (Ser40) Antibody (YA169) NFE2L2; NRF2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2	WB, IHC-P	Human
	Phospho-Nrf2 (Ser40) Antibody (YA169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Nrf2 (Ser40).

HY-P80841A

	Phospho-Nrf2 (Ser40) Antibody (YA169)(PBS only) NFE2L2; NRF2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2	WB, IHC-P	Human
	Phospho-Nrf2 (Ser40) Antibody (YA169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Nrf2 (Ser40).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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