948044-25-5
948044-25-5
Chemical Structure
ACA-28
- CAS No.: 948044-25-5
- Formula:C17H16O6
- Molecular Weight:316.31
IUPAC Name: 4-(((methoxycarbonyl)oxy)(phenyl)methyl)phenyl methyl carbonate
InChIKey: UZLVJKSHIATGCE-UHFFFAOYSA-N
SMILES: O=C(OC)OC1=CC=C(C(C2=CC=CC=C2)OC(OC)=O)C=C1
Biological Activity: ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma [1][2].
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ACA-28 | 99.70% | ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma . | ||||||||||||||||||||
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References
- [1]. Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137. [Content Brief]
- [2]. Takasaki T, et al. ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells. Oxid Med Cell Longev. 2024 Mar 11;2024:7683793. [Content Brief]
Keywords
