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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
nucleolus
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "nucleolus" in MCE Product Catalog:
15
15 Cited Publications
Target:
연구분야:
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .
Target:
연구분야:
UNC6934 is a selective NSD2-PWWP1 antagonist with a Kd of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma .
Cat. No.: HY-175783
CAS No.: 3065567-21-4
MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) .
Cat. No.: HY-118723
CAS No.: 309726-06-5
Target:
연구분야:
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .
Target:
Hydrocortisone phosphate (Hydrocortisone 21-phosphate) is a derivative of the glucocorticoid Hydrocortisone hemisuccinate (HY-B1402) that increases serum luteinizing hormone (LH) levels. Hydrocortisone phosphate increases the activity of magnesium-dependent polymerases in the nucleolus. Hydrocortisone phosphate also serves as a substrate for alkaline phosphatase to localize phosphatases that hydrolyze steroid phosphates, and the role of alkaline phosphatase has been validated in adult mouse tissues .
Cat. No.: HY-P11651
CAS No.: 433257-50-2
Cat. No.: HY-D3415
CAS No.: 3030070-69-7
Cat. No.: HY-179540
Synonyms: 5-BrUTP trisodium
연구분야:
5-Bromo-UTP (5-BrUTP) trisodium is a derivative of uridine triphosphate (UTP). 5-Bromo-UTP trisodium can be utilized by cells as a precursor for RNA synthesis. During transcription, it integrates into the newly synthesized RNA chain and replaces some UTP. 5-Bromo-UTP trisodium can be used to label newly synthesized RNA, thereby enabling high-resolution visualization of transcriptional sites and RNA transport .
Cat. No.: HY-P87040
Synonyms: 90 kDa nucleolus organizer region autoantigen antibody; Autoantigen NOR-90 antibody; NOR 90 antibody; Nucleolar transcription factor 1 antibody; UBF 1 antibody; UBF antibody; UBF-1 antibody; UBF1_HUMAN antibody; Ubtf antibody; Upstream binding factor 1 antibody; 90 kDa nucleolus organizer region autoantigen antibody; Autoantigen NOR-90 antibody; NOR 90 antibody; Nucleolar transcription factor 1 antibody; UBF 1 antibody; UBF antibody; UBF-1 antibody; UBF1_HUMAN antibody; Ubtf antibody; Upstream binding factor 1 antibody; upstream binding transcription factor, RNA polymerase I antibody; Upstream-binding factor 1 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
