309726-06-5
Chemical Structure
BMH-22
- CAS. Nr.: 309726-06-5
- Formula:C16H17N3
- Molecular Weight:251.33
IUPAC Name: 2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine
InChIKey: ZNPSDSMZKLWRLO-UHFFFAOYSA-N
SMILES: CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C
Biological Activity: BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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BMH-22 | 98.85% | BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types. | ||||||||||||||||||||
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