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15 Results for "
phosphoramidate
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "phosphoramidate" in MCE Product Catalog:
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1 Cited Publications
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NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer .
Synonyms: INX-08189
BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2’-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection .
Synonyms: Remdesivir isopropyl ester analog
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Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV) .
Synonyms: NB1011
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Thymectacin (NB1011) is an agent selectively targeting tumor cells that have a high expression of thymidylate synthase (TS). Thymectacin is an aryloxy phosphoramidate derivative of BVdU (brivudin) .
Cat. No.: HY-W881466
CAS No.: 2419895-65-9
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5'(E)-VP-2'-OMe-Bz-A Phosphoramidite is a phosphoramidate nucleotide precursor compound, which is mainly used to synthesize stable and functionalized modified oligonucleotides and is used in the development and synthesis of nucleic acid drugs .
Cat. No.: HY-W010778
CAS No.: 231278-20-9
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N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs.
Cat. No.: HY-168913
CTT2274 is a prodrug of MMAE (HY-15162). CTT2274 is composed of a prostate-specific membrane antigen (PSMA)-binding scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. CTT2274 shows selective binding to PSMA and delivers MMAE. CTT2274 inhibits prostate cancer .
Cat. No.: HY-176175S
CAS No.: 1631170-04-1
Cat. No.: HY-131233R
CAS No.: 1911578-83-0
Synonyms: Remdesivir isopropyl ester analog (Standard)
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Anti-virus agent 1 (Standard) is the analytical standard of Anti-virus agent 1. This product is intended for research and analytical applications. Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2].
Cat. No.: HY-W1061635
CAS No.: 936471-68-0
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5'-Amino-modifier C4-TFA Phosphoramidite is a non-nucleoside phosphoramidate monomer that can be used for the synthesis of solid-phase oligonucleotides.
Cat. No.: HY-W1061634
CAS No.: 164394-19-8
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5'-Amino-modifier C6-Fmoc Phosphoramidite is a non-nucleoside phosphoramidate monomer used in solid-phase oligonucleotide synthesis to introduce a protected primary amino group (-NH2) at the 5' end of DNA/RNA.
Cat. No.: HY-185993
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PT-IX Phosphoramidite is a non-nucleotide phosphoramidate reagent that can be used to introduce specific functional groups or modified structures during the synthesis of oligonucleotides. These modifications can confer special physical, chemical or biological properties to the synthesized DNA or RNA molecules, and are widely applied in molecular diagnostics, gene function research, and the development of therapeutic drugs such as nucleic acid aptamers.
Cat. No.: HY-189131
CAS No.: 1628717-55-4
Synonyms: CTT-1057
Vidoflufolastat (CTT-1057) is a PSMA inhibitor with an IC50 of 0.4 nM. Vidoflufolastat binds irreversibly to the active-site zinc ion through its phosphoramidate core, while its distal fluorobenzoyl ring interacts with the arene-binding site. Vidoflufolastat can be used in research on prostate cancer and Pseudomonas aeruginosa infection .
Cat. No.: HY-183873
CAS No.: 2850362-12-6
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HLB-0532247 is a cell-permeable phosphoramidate prodrug of 3'-deoxy-3',4'-didehydrocytidine (ddhC). HLB-0532247 increases the intracellular level of the endogenous antiviral nucleotide ddhCTP (HY-128788). HLB-0532247 reduces the titers of Zika virus and West Nile virus in cell cultures. HLB-0532247 can be used in studies related to Zika virus infection, West Nile virus infection, and coronavirus infection .
Cat. No.: HY-184783
CAS No.: 1631170-16-5
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N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester is a 5'(S)-C-methyl phosphoramidate prodrug of 2',5'-C-dimethyluridine, as well as a HCV inhibitor. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester induces anti-HCV activity in HCV genotype 1b replicons with extremely low cytotoxicity. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester can be used in studies related to HCV infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
