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Results for "

phosphoribosyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Adenosine Receptor (1) Akt (1) Antibiotic (1) Apoptosis (9) ATTECs (1) Autophagy (5) Carbonic Anhydrase (1) Cytochrome P450 (1) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (10) ERK (3) HDAC (2) HIV (1) Influenza Virus (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (6) Ligands for Target Protein for PROTAC (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) mTOR (2) NAMPT (29) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) PAK (1) Parasite (4) PD-1/PD-L1 (1) PROTACs (3) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SARS-CoV (1) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (32) Infection (6) Inflammation/Immunology (1) Metabolic Disease (9) Neurological Disease (7)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

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Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-F0004

Fosribnicotinamide 25+ Cited Publications β-Nicotinamide mononucleotide; β-NM; NMN	Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-50876

Daporinad Maximum Cited Publications 64 Publications Verification FK866; APO866	NAMPT Autophagy Apoptosis mTOR p38 MAPK ERK	Cancer
Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a K_i value of 0.3 nM. Daporinad depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad can be used for the study of myeloma, liver cancer, and immunosuppression .

HY-122502

Pyrazofurin 2 Publications Verification Pirazofurin	DNA/RNA Synthesis Antibiotic Influenza Virus HIV SARS-CoV	Infection Cancer
Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a *orotate-phosphoribosyltransferase* inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity .

HY-147193

Nampt-IN-10 TFA	NAMPT	Cancer
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC₅₀s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .

HY-12793

Padnarsertib 3 Publications Verification KPT-9274	PAK NAMPT	Cancer
Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC₅₀s of <100 nM and 120 nM, respectively .

HY-10079

CHS-828 4 Publications Verification GMX1778	NAMPT Apoptosis	Cancer
CHS-828 (GMX1778) is a competitive inhibitor of *nicotinamide phosphoribosyltransferase* (NAMPT), with an IC₅₀** less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-126255

SBI-797812 2 Publications Verification	NAMPT	Metabolic Disease
SBI-797812 is an orally active *nicotinamide phosphoribosyltransferase* (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT**, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD ⁺. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD ⁺ in mice .

HY-W070294

8-Azahypoxanthine	DNA/RNA Synthesis	Cancer
8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT). 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma .

HY-148815

Nampt activator-1	NAMPT	Metabolic Disease
Nampt activator-1 is a nicotinamide phosphoribosyltransferase (NAMPT) activator, with an EC₅₀ of 3.3~3.7 μM. Nampt activator-1 enhances the enzymatic activity of NAMPT. Nampt activator-1 can be used for research related to metabolic disorders .

HY-F0004S

Fosribnicotinamide-d4 β-Nicotinamide mononucleotide-d₄; β-NM-d₄; NMN-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide-d₄ (β-Nicotinamide mononucleotide-d₄) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-N8060A

Orotidine 5′-monophosphate trisodium 1 Publications Verification Orotidine monophosphate trisodium; Orotidylic acid trisodium	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-14373

CB30865 ZM 242421	NAMPT	Cancer
CB30865 (ZM 242421) is a *nicotinamide phosphoribosyltransferase* (Nampt)** inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range) . CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119413

9-Ethyladenine	Adenosine Receptor	Neurological Disease
9-Ethyladenine is a precursor of competitive antagonists of adenosine receptors (A₁, A₂, A₃), with no significant inhibitory effect on adenine phosphoribosyltransferase (APRT). 9-Ethyladenine derivatives have high affinity and selectivity for A₁ (K_i=27 nM), A₂A (K_i=46 nM), and A₃ (K_i=86 nM) receptors. 9-Ethyladenine does not inhibit brain APRT activity, can be used in the study of adenosine receptor-related diseases (such as nervous system diseases) models .

HY-W013111

2′-Deoxy-GDP trisodium dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium	Nucleoside Antimetabolite/Analog Parasite	Infection
2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a *hypoxanthine phosphoribosyltransferase* (HGPRT) inhibitor with an IC₅₀** of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .

HY-N9941

2,8-Dihydroxyadenine	Endogenous Metabolite	Metabolic Disease
2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency .

HY-108701

Nampt-IN-3	NAMPT HDAC Autophagy Apoptosis	Cancer
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC₅₀s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death .

HY-F0004R

Fosribnicotinamide (Standard) β-Nicotinamide mononucleotide (Standard); β-NM (Standard); NMN (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease Cancer
Fosribnicotinamide (Standard) (β-Nicotinamide mononucleotide (Standard)) is the analytical standard of Fosribnicotinamide (HY-F0004 ). This product is intended for research and analytical applications. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-163499

NAMPT activator-7	NAMPT	Cancer
NAMPT activator-7 (Compound 232) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-7 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-163500

NAMPT activator-8	NAMPT	Cancer
NAMPT activator-8 (Compound 278) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-8 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-147193A

Nampt-IN-10 trihydrochloride	NAMPT	Cancer
Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC₅₀ values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC) .

HY-163280

JGB-1-155	NAMPT	Neurological Disease
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC₅₀ of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD ⁺ in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .

HY-W1117786

Nampt-IN-10	ADC Payload NAMPT	Cancer
Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity .

HY-158323

HGPRT/TBrHGPRT1-IN-1	Parasite	Infection Cancer
HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both K_i=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer .

HY-N5134S5

5'-Guanylic acid-13C10,15N5 dilithium 5'-GMP-13C10,15N5 dilithium; 5'-guanosine monophosphate-13C10,15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹³C₁₀, ¹⁵N₅ (5'-GMP- ¹³C₁₀, ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-W587952

Gibberellin A34	NAMPT	Others
Gibberellin A34 is a Hypoxanthine guanine phosphoribosyltransferase 1 (HPRT1) inhibitor that can be isolated from immature seeds of Calonyction aculeatum. Gibberellin A34 can be used for studies on plant growth and development regulation .

HY-144294

*Purine phosphoribosyltransferase-IN-1*	Parasite	Infection
Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with K_i values of 50, 20, and 2 nM, respectively .

HY-144296

*Purine phosphoribosyltransferase-IN-2*	Parasite	Infection
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with K_is of 30, 20 and 2 nM, respectively .

HY-130606

Nampt-IN-5	NAMPT Cytochrome P450	Cancer
Nampt-IN-5 is a potent *nicotinamide phosphoribosyltransferase* (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC₅₀**s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively .

HY-147656

NAMPT degrader-1	ATTECs NAMPT Autophagy	Cancer
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an *nicotinamide phosphoribosyltransferase* (NAMPT) degrader with an IC₅₀ of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy**-lysosomal pathway and shows excellent cellular antitumor potency .

HY-159009

MS7	NAMPT Ligands for Target Protein for PROTAC	Cancer
MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD ⁺ required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research .

HY-W010354

2,2-Diethoxyethanol	Drug Intermediate	Infection
2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection .

HY-175294

PD-L1/Nampt-IN-1	PD-1/PD-L1 NAMPT	Cancer
PD-L1/Nampt-IN-1 is an orally active inhibitor that simultaneously target PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase) with IC₅₀s value of 63 nM and 582 nM. PD-L1/Nampt-IN-1 demonstrates cross-species affinity with comparable K_D values for hPD-L1 (52.6 nM) and mPD-L1 (49.1 nM), respectively. PD-L1/Nampt-IN-1 effectively inhibits tumor growth by activating the tumor immune microenvironment. PD-L1/Nampt-IN-1 can be used for the study of melanoma .

HY-101280A

LB-60-OF61 hydrochloride	NAMPT	Cancer
LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines .

HY-159016

SIAIS630121-NC	PROTACs	Cancer
SIAIS630121-NC (compound 630121-NC) is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) PROTAC degrader SIAIS630121. SIAIS630121-NC shows no NAMPT degradation capability at all .

HY-10079A

CHS-828 (nicotinate) GMX1778 (nicotinate)	NAMPT Apoptosis	Cancer
CHS-828 nicotinate is a competitive inhibitor of *nicotinamide phosphoribosyltransferase* (NAMPT), with an IC₅₀** less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-159015

SIAIS630120-NC	PROTACs	Cancer
SIAIS630120-NC is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) degrader SIAIS630120 (Sturcture Note:(Blue: Cereblon ligand Thalidomide (HY-14658) analogue (HY-138793), Black: linker；Pink: Nampt inhibitor FK866 (HY-50876)) .

HY-10079R

CHS-828 (Standard) GMX1778 (Standard)	Reference Standards NAMPT Apoptosis	Cancer
CHS-828 (Standard) is the analytical standard of CHS-828. This product is intended for research and analytical applications. CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity .

HY-N5134S2

5'-Guanylic acid-15N5 dilithium 5'-GMP-15N5 dilithium; 5'-guanosine monophosphate-15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹⁵N₅ (5'-GMP- ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹⁵N₅) dilithium is ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S1

5'-Guanylic acid-13C10 dilithium 5'-GMP-13C10 dilithium; 5'-guanosine monophosphate-13C10 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹³C₁₀ (5'-GMP- ¹³C₁₀ dilithium; 5'-guanosine monophosphate- ¹³C₁₀) dilithium is ¹³C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S3

5'-Guanylic acid-d12 dilithium 5'-GMP-d12 dilithium; 5'-guanosine monophosphate-d12 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid-d₁₂ (5'-GMP-d₁₂ dilithium; 5'-guanosine monophosphate-d₁₂) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-158319

Mutant IDH1/NAMPT-IN-1	Apoptosis Isocitrate Dehydrogenase (IDH) NAMPT	Cancer
Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC₅₀=14.93 nM) and *nicotinamide phosphoribosyltransferase* (NAMPT) (IC₅₀=12.56 nM). Mutant IDH1/NAMPT-IN-1 can induce apoptosis**. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively .

HY-N5134S4

5'-Guanylic acid-15N5,d12 dilithium 5'-GMP-15N5,d12 dilithium; 5'-guanosine monophosphate-15N5,d12 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹⁵N₅,d₁₂ (5'-GMP- ¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate- ¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-181880

PROTAC NAMPT Degrader-28	PROTACs NAMPT	Cancer
PROTAC NAMPT Degrader-28 is a NAMPT PROTAC degrader with DC₅₀ values of 45 nM and 55 nM in MCF7 and 4T1cl5 cells, respectively. PROTAC NAMPT Degrader-28 retains nicotinamide phosphoribosyltransferase inhibitory activity and does not induce degradation of this enzyme. PROTAC NAMPT Degrader-28 can be used in breast cancer-related research .

HY-182567

Nampt-IN-19	NAMPT	Cancer
Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human K_i of 5.6 nM. Nampt-IN-19 blocks NAD ⁺ biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer .

HY-186105

P7C3-S243	NAMPT	Neurological Disease
P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease .

HY-181350

CAIX/XII/NAMPT-IN-1	Carbonic Anhydrase NAMPT Apoptosis Reactive Oxygen Species (ROS) ERK Akt DNA/RNA Synthesis Mitochondrial Metabolism	Cancer
CAIX/XII/NAMPT-IN-1 is a triple inhibitor of carbonic anhydrase IX/XII and nicotinamide phosphoribosyltransferase (NAMPT) with a hCA IX K_i of 78.1 nM, hCA XII K_i of 64.4 nM, and hNAMPT IC₅₀ of 168 nM. CAIX/XII/NAMPT-IN-1 induces apoptosis, ROS accumulation, suppresses ERK/AKT signaling, inhibits DNA synthesis, and causes mitochondrial dysfunction. CAIX/XII/NAMPT-IN-1 exerts antiproliferative effects against multiple cancer cells under normoxic and hypoxic conditions. CAIX/XII/NAMPT-IN-1 can be used for the research of cancer, such as renal carcinoma, glioblastoma and colorectal cancer .

HY-181882

MV78-OH-C7-COOH	Target Protein Ligand-Linker Conjugates	Others
MV78-OH-C7-COOH is a synthetic target protein ligand-linker conjugate that can be used for the synthesis of PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880) .

HY-108701R

Nampt-IN-3 (Standard)	Reference Standards NAMPT HDAC Autophagy Apoptosis	Cancer
Nampt-IN-3 (Standard) is the analytical standard of Nampt-IN-3 (HY-108701). This product is intended for research and analytical applications. Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC₅₀s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death .

HY-179523

Carba1	Drug Derivative NAMPT Microtubule/Tubulin	Neurological Disease Cancer
Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN) .

HY-50876A

Daporinad hydrochloride FK866 hydrochloride; APO866 hydrochloride	NAMPT Autophagy Apoptosis mTOR p38 MAPK ERK	Inflammation/Immunology Cancer
Daporinad (FK866) hydrochloride is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a K_i value of 0.3 nM. Daporinad hydrochloride depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad hydrochloride causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad hydrochloride induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad hydrochloride can be used for the study of myeloma, liver cancer, and immunosuppression .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-F0004

Fosribnicotinamide 25+ Cited Publications β-Nicotinamide mononucleotide; β-NM; NMN	Human Gut Microbiota Metabolites Microorganisms Other disease Neurological Disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-N8060A

Orotidine 5′-monophosphate trisodium 1 Publications Verification Orotidine monophosphate trisodium; Orotidylic acid trisodium	Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-119413

9-Ethyladenine	Natural Products Microorganisms Neurological Disease Classification of Application Fields Disease Research Fields Source Classification	Adenosine Receptor
9-Ethyladenine is a precursor of competitive antagonists of adenosine receptors (A₁, A₂, A₃), with no significant inhibitory effect on adenine phosphoribosyltransferase (APRT). 9-Ethyladenine derivatives have high affinity and selectivity for A₁ (K_i=27 nM), A₂A (K_i=46 nM), and A₃ (K_i=86 nM) receptors. 9-Ethyladenine does not inhibit brain APRT activity, can be used in the study of adenosine receptor-related diseases (such as nervous system diseases) models .

HY-N9941

2,8-Dihydroxyadenine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency .

HY-F0004R

Fosribnicotinamide (Standard) β-Nicotinamide mononucleotide (Standard); β-NM (Standard); NMN (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Fosribnicotinamide (Standard) (β-Nicotinamide mononucleotide (Standard)) is the analytical standard of Fosribnicotinamide (HY-F0004 ). This product is intended for research and analytical applications. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-W587952

Gibberellin A34	Structural Classification Ketones, Aldehydes, Acids Plants Convolvulaceae Ipomoea alba Linnaeus Source Classification	NAMPT
Gibberellin A34 is a Hypoxanthine guanine phosphoribosyltransferase 1 (HPRT1) inhibitor that can be isolated from immature seeds of Calonyction aculeatum. Gibberellin A34 can be used for studies on plant growth and development regulation .

HY-W010354

2,2-Diethoxyethanol	Structural Classification Natural Products Cestrum nocturnum Linn. Solanaceae Plants Source Classification	Drug Intermediate
2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection .

Species:	Human (6) Mouse (2)
Tag:	SUMO (1) His (7) Strep (1) Tag Free (1) Myc (1) GST (1) Flag (1)
Source:	Sf9 insect cells (2) P. pastoris (1) E. coli (6)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P70227

	HGPRT Protein, Human (His) rHuHypoxanthine-guanine phosphoribosyltransferase/HGPRT, His; Hypoxanthine-Guanine phosphoribosyltransferase; HGPRT; HGPRTase; HPRT1; HPRT	Human	E. coli
	HGPRT proteins play a key role in purine metabolism, promoting the conversion of guanine to guanosine monophosphate and hypoxanthine to inosine monophosphate. Through its enzymatic activity, HGPRT transfers the 5-phosphate ribosyl group from 5-phosphate ribose pyrophosphate to purine, making a significant contribution to the purine salvage pathway. HGPRT Protein, Human (His) is the recombinant human-derived HGPRT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71417

	UPRT Protein, Human (His) Uracil phosphoribosyltransferase homolog; UPP; FUR1; UPRT	Human	E. coli
	Uracil phosphoribosyltransferase homolog (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP) which is an important part of nucleotide metabolism. UPRT localizes to the nucleus and cytoplasm, and is a potential target for rational design of drugs to treat parasitic infections and cancer. UPRT Protein, Human (His) is the recombinant human-derived UPRT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701314

	NAMPT Protein, Mouse 3 Publications Verification rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Mouse	E. coli
	NAMPT protein has dual functions of cytokine and adipokine. Due to limited ATP activation, its secreted form lacks enzymatic activity. It catalyzes the condensation of nicotinamide and 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide, which is critical for NAD biosynthesis. NAMPT Protein, Mouse is the recombinant mouse-derived NAMPT protein, expressed by E. coli , with tag free.

HY-P77158

	PRTFDC1 Protein, Human (His) phosphoribosyltransferase domain-containing protein 1; HHGP	Human	E. coli
	PRTFDC1 protein, with minimal phosphoribosyltransferase activity, shows low in vitro detection levels. It binds GMP, IMP, and PRPP, yet its involvement in purine metabolism or salvage is not expected. Functioning as a homodimer, its structural configuration highlights its role in cellular processes. PRTFDC1 Protein, Human (His) is the recombinant human-derived PRTFDC1 protein, expressed by E. coli , with N-His labeled tag.

HY-P70353

	NAMPT Protein, Human (His) 4 Publications Verification rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Human	E. coli
	NAMPT protein catalyzes the synthesis of nicotinamide mononucleotide, a key intermediate in NAD biosynthesis. NAMPT Protein, Human (His) is the recombinant human-derived NAMPT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70971

	QPRTase Protein, Human (His) Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]; Quinolinate phosphoribosyltransferase [Decarboxylating]; QAPRTase; QPRTase; QPRT	Human	E. coli
	QPRTase Protein, Human (His) is the recombinant human-derived QPRTase protein, expressed by E. coli, with N-6*His labeled tag.

HY-P701315

	NAMPT Protein, Mouse (P.pastoris, His) rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Mouse	P. pastoris
	NAMPT protein has dual functions of cytokine and adipokine. Due to limited ATP activation, its secreted form lacks enzymatic activity. It catalyzes the condensation of nicotinamide and 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide, which is critical for NAD biosynthesis. NAMPT Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived NAMPT protein, expressed by P. pastoris , with N-10*His labeled tag.

HY-P704014

	NAMPT Protein, Human (sf9, His, GST) rHuNicotinamide phosphoribosyltransferase/NAMPT, His; Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1	Human	Sf9 insect cells
	NAMPT protein catalyzes the synthesis of nicotinamide mononucleotide, a key intermediate in NAD biosynthesis. NAMPT Protein, Human (sf9, His, GST) is the recombinant human-derived NAMPT protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

HY-P72047

	APT Protein, Streptococcus pyogenes serotype M1 (sf9, His-Myc) apt; SPy_0927; M5005_Spy0728Adenine phosphoribosyltransferase; APRT; EC 2.4.2.7	Others	Sf9 insect cells
	APT, also known as adenine phosphoribosyltransferase, plays a crucial role in the rescue reaction that forms AMP (adenosine monophosphate). This salvage pathway provides a more energy-efficient route for AMP synthesis than de novo synthesis. APT Protein, Streptococcus pyogenes serotype M1 (sf9, His-Myc) is the recombinant APT protein, expressed by sf9 insect cells , with N-10*His, C-Myc labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-F0004S

Fosribnicotinamide-d4

Fosribnicotinamide-d₄ (β-Nicotinamide mononucleotide-d₄) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

HY-N5134S5

5'-Guanylic acid-13C10,15N5 dilithium

5'-Guanylic acid- ¹³C₁₀, ¹⁵N₅ (5'-GMP- ¹³C₁₀, ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S2

5'-Guanylic acid-15N5 dilithium
5'-Guanylic acid- ¹⁵N₅ (5'-GMP- ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹⁵N₅) dilithium is ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S1

5'-Guanylic acid-13C10 dilithium
5'-Guanylic acid- ¹³C₁₀ (5'-GMP- ¹³C₁₀ dilithium; 5'-guanosine monophosphate- ¹³C₁₀) dilithium is ¹³C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S3

5'-Guanylic acid-d12 dilithium
5'-Guanylic acid-d₁₂ (5'-GMP-d₁₂ dilithium; 5'-guanosine monophosphate-d₁₂) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S4

5'-Guanylic acid-15N5,d12 dilithium

5'-Guanylic acid- ¹⁵N₅,d₁₂ (5'-GMP- ¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate- ¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

Host:	Mouse (3) Rabbit (4)
Reactivity:	Human (7) Mouse (2) Rat (3) Monkey (2) Rabbit (2)
Application:	IHC-P (5) ICC/IF (2) IP (1) WB (5) FC (2) ELISA (3)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Unmodified (5)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P83255

	HPRT Antibody (YA3000) HPRT1; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase	WB, IP	Human, Rat
	HPRT Antibody (YA3000) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HPRT.

HY-P85202

	HPRT Antibody (YA4894) HPRT1; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase	WB, ELISA	Human
	HPRT Antibody (YA4894) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HPRT.

HY-P87047

	QPRT Antibody (YA6740) NADC_HUMAN antibody; Nicotinate nucleotide pyrophosphorylase (carboxylating) antibody; Nicotinate-nucleotide pyrophosphorylase [carboxylating] antibody; QAPRTase antibody; QPRT antibody; QPRTase antibody; Quinolinate phosphoribosyltransferase [decarboxylating] antibody; Quinolinate phosphoribosyltransferase antibody;	WB, IHC-P	Human
	QPRT Antibody (YA6740) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to QPRT.

HY-P81438

	Visfatin Antibody (YA1183) Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	IHC-P	Human
	Visfatin Antibody (YA1183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Visfatin.

HY-P81438A

	Visfatin Antibody (YA1183)(PBS only) Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	IHC-P	Human
	Visfatin Antibody (YA1183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Visfatin.

HY-P85319

	Visfatin Antibody (YA5011) NAMPT; PBEF; PBEF1; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit
	Visfatin Antibody (YA5011) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Visfatin.

HY-P85319A

	Visfatin Antibody (YA5011)(PBS only) NAMPT; PBEF; PBEF1; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Mouse, Monkey, Rabbit
	Visfatin Antibody (YA5011) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Visfatin.