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purine nucleoside phosphorylase

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By Targets:	Nucleoside Antimetabolite/Analog (11) Phosphorylase (1) Apoptosis (2) DNA/RNA Synthesis (2) Drug Derivative (1) Endogenous Metabolite (10) Fluorescent Dye (1) HIV (3) Isotope-Labeled Compounds (1) Reference Standards (3)
By Research Areas:	Cancer (10) Infection (4) Inflammation/Immunology (5) Metabolic Disease (10) Neurological Disease (2)
Oligonucleotides:	Adenosine (1) Guanosine (3) Nucleoside Analogs (5) Inosine (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Phosphorylase Nucleoside Transporters Nucleoside Antimetabolite/Analog NTPDase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-16210

Forodesine Maximum Cited Publications 19 Publications Verification BCX-1777; Immucillin-H	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Fluorescent Dye	Others
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

HY-16209

Forodesine hydrochloride Maximum Cited Publications 19 Publications Verification BCX-1777 hydrochloride; Immucillin-H hydrochloride	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Infection Cancer
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Endogenous Metabolite	Metabolic Disease
Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀ value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Endogenous Metabolite	Neurological Disease
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-P2724

Purine nucleoside phosphorylase, Microorganism PNP	Endogenous Metabolite	Metabolic Disease
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .

HY-W008638

2'-Deoxyinosine 2 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-	Nucleoside Antimetabolite/Analog Drug Derivative	Metabolic Disease
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human **purine nucleoside phosphorylase** via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-121106

9-Deazaguanine 1 Publications Verification	DNA/RNA Synthesis	Others
9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP) .

HY-106934A

Peldesine dihydrochloride 1 Publications Verification BCX 34 dihydrochloride	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .

HY-139037

8-Aminoguanine	Endogenous Metabolite	Metabolic Disease
8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-W008638R

2'-Deoxyinosine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
2'-Deoxyinosine (Standard) is the analytical standard of 2'-Deoxyinosine (HY-W008638). This product is intended for research and analytical applications. 2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-113468R

3-O-Methyl-DL-DOPA (Standard) 3-Methoxytyrosine (Standard)	Endogenous Metabolite Reference Standards	Neurological Disease
3-O-Methyl-DL-DOPA (Standard) is the analytical standard of 3-O-Methyl-DL-DOPA. This product is intended for research and analytical applications. 3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency [4].

HY-P2724A

Purine nucleoside phosphorylase, Bacillus sp. PNP, Bacillus sp.	Endogenous Metabolite	Metabolic Disease
Purine nucleoside phosphorylase, Bacillus sp. is a key enzyme in purine metabolism, involved in the purine salvage pathway. A deficiency in Purine nucleoside phosphorylase, Bacillus sp. can lead to impaired T-cell function. In the presence of inorganic phosphate as a second substrate, Purine nucleoside phosphorylase, Bacillus sp. catalyzes the cleavage of the glycosidic bond of ribonucleosides and deoxyribonucleosides, producing purine bases and ribose (or deoxyribose)-1-phosphate. Purine nucleoside phosphorylase, Bacillus sp. can be used for the determination of inorganic phosphate .

HY-111627

5-Aza-7-deazaguanine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli **purine nucleoside phosphorylase** and its Ser90Ala mutant in the synthesis of base-modified nucleosides .

HY-106934

Peldesine BCX 34	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .

HY-W750387

Immucillin-G	Nucleoside Antimetabolite/Analog	Metabolic Disease
Immucillin-G is a **purine nucleoside phosphorylase (PNP**) inhibitor. Immucillin-G can reduce urate levels and can be used for the research of metabolic disease, such as hyperuricemia .

HY-118047

CI 972 anhydrous	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (K_i=0.83 μM) under development as a T cell-selective immunosuppressive agent .

HY-W771063

8-Aminoguanine-13C2,15N	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
8-Aminoguanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-136508

8-Aminoguanosine	Phosphorylase DNA/RNA Synthesis	Cancer
8-Aminoguanosine is a **purine nucleoside phosphorylase** inhibitor. 8-Aminoguanosine blocks purine nucleoside phosphorylation via specific binding .

HY-106934AR

Peldesine dihydrochloride (Standard) BCX 34 dihydrochloride (Standard)	Nucleoside Antimetabolite/Analog HIV Reference Standards	Infection Inflammation/Immunology Cancer
Peldesine (dihydrochloride) (Standard) is the analytical standard of Peldesine (dihydrochloride). This product is intended for research and analytical applications. Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .

HY-106421

BCX-5 PD 141955	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a K_i of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology .

HY-P3241A

Nucleoside Phosphorylase, bacterial	Endogenous Metabolite	Metabolic Disease
Nucleoside Phosphorylase, bacterial (EC 2.4.2.1), is a pentosesyltransferase. Nucleoside Phosphorylase participates in three metabolic pathways: purine metabolism, pyrimidine metabolism, and nicotinic acid and nicotinamide metabolism. Its two substrates are purine nucleosides and phosphates, and its two products are purines and α-D-ribose-1-phosphate.

Cat. No.	상품명

HY-L044

Nucleotide Compound Library	572 compounds
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications. MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	상품명	Type

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Fluorescent Dyes
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-19480

Ulodesine 1 Publications Verification BCX4208	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀ value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-W008638R

2'-Deoxyinosine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2'-Deoxyinosine (Standard) is the analytical standard of 2'-Deoxyinosine (HY-W008638). This product is intended for research and analytical applications. 2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-113468R

3-O-Methyl-DL-DOPA (Standard) 3-Methoxytyrosine (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-O-Methyl-DL-DOPA (Standard) is the analytical standard of 3-O-Methyl-DL-DOPA. This product is intended for research and analytical applications. 3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency [4].

Species:	Human (1)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P701869

	Purine nucleoside phosphorylase Protein, Thermus thermophilus purine nucleoside phosphorylase	Others	E. coli
	Purine nucleoside phosphorylase Protein, Thermus thermophilus is the recombinant Purine nucleoside phosphorylase protein, expressed by E. coli, with tag free.

HY-P701870

	Purine nucleoside phosphorylase Protein, Thermus thermophilus (His) purine nucleoside phosphorylase	Others	E. coli
	Purine nucleoside phosphorylase Protein, Thermus thermophilus (His) is the recombinant Purine nucleoside phosphorylase protein, expressed by E. coli, with N-6*His labeled tag.

HY-P74665

	Nucleoside phosphorylase/PNP Protein, Human (His) purine nucleoside phosphorylase; PNP; Inosine phosphorylase; NP	Human	E. coli
	Nucleoside phosphorylase/PNP proteins play a vital role in cellular processes by catalyzing the phosphate breakdown of β-(deoxy)ribonucleosides, preferably 6-oxopurine nucleosides, such as inosine and guanosine. This enzymatic activity results in the formation of free purine bases and pentose 1-phosphate, highlighting the importance of this protein in regulating nucleoside degradation. Nucleoside phosphorylase/PNP Protein, Human (His) is the recombinant human-derived Nucleoside phosphorylase/PNP protein, expressed by E. coli , with C-10*His labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-W771063

8-Aminoguanine-13C2,15N
8-Aminoguanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

Cat. No.	상품명		Classification

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG		Nucleoside Analogs Guanosine
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification		Nucleoside Analogs Adenosine
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-W008638

2'-Deoxyinosine 2 Publications Verification		Nucleoside Analogs Inosine
2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-		Nucleoside Analogs Guanosine
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human **purine nucleoside phosphorylase** via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-111627

5-Aza-7-deazaguanine 1 Publications Verification		Nucleoside Analogs Guanosine
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli **purine nucleoside phosphorylase** and its Ser90Ala mutant in the synthesis of base-modified nucleosides .

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purine nucleoside phosphorylase

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products