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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
rat insulinoma cells
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "rat insulinoma cells" in MCE Product Catalog:
77
1
1 Cited Publications
Synonyms: LY2608204; SY-004
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Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes .
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Neomycin, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin is a known phospholipase C (PLC) inhibitor. Neomycin potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin inhibits IP3-mediated Ca 2+ release, MgATP-dependent Ca 2+ uptake, and electrical excitation-evoked skeletal muscle Ca 2+ transients. Neomycin depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin can be used for the research of cancer .
Cat. No.: HY-P10927A
Synonyms: BRINP2-related peptide TFA
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Cat. No.: HY-P10927
Synonyms: BRINP2-related peptide
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Category:
Infection Simple Phenylpropanols Solanum torvum Swartz Phenols Polyphenols Phenylpropanoids Plants Solanaceae Disease Research Fields
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Cat. No.: HY-176040
CAS No.: 956783-34-9
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IXA62 is an orally active and selective IRE1/XBP1s activator (EC50 = 0.31 μM) that reduces Aβ secretion. IXA62 enhances glucose-stimulated insulin secretion from rat insulinoma cells .
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DP-b99 is a blood-brain barrier-permeable inhibitor of CYP2C9 and MMP-9, with a Ki value of 4.655 μM against CYP2C9. DP-b99 inhibits CYP2C9 via apparent non-competitive inhibition, mainly chelates pathological Zn 2+ in the membrane environment, attenuates the elevation of intracellular Zn 2+ and Ca 2+ levels, delays seizure onset and reduces seizure severity, and also prevents MMP-9-dependent dendritic spine remodeling, β-dystroglycan cleavage and gelatinase activity. DP-b99 can be used in the research of acute ischemic stroke, epileptogenesis and stroke .
Cat. No.: HY-148235
CAS No.: 858097-86-6
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TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes .
Cat. No.: HY-P1544
CAS No.: 94071-26-8
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Cat. No.: HY-170593
CAS No.: 3067202-14-3
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ChREBPα/14-3-3 regulator-1 is a molecular glue that selectively stabilizes ChREBPα/14-3-3 PPI, with an EC50 of 3.8 μM. ChREBPα/14-3-3 regulator-1 sequesters ChREBPα in the cytoplasm, inhibits ChREBPβ and TXNIP responses, reduces glucolipotoxicity-induced β-cell death, and maintains β-cell identity and function. ChREBPα/14-3-3 regulator-1 can be used in studies related to type 2 diabetes .
Cat. No.: HY-P11945
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Cat. No.: HY-183955
CAS No.: 2041071-54-7
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GNF7156 is a DYRK1A/GSK3B inhibitor, IC50 values of 100 nM for DYRK1A and 40 nM for GSK3B. GNF7156 inhibits DYRK1A and GSK3B kinase activity and induces NFAT nuclear retention. GNF7156 stimulates beta-cell cycle entry and division and maintains insulin secretory capacity. GNF7156 can be used for the research of type 1 diabetes, and type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
