26 Results for "

respiratory muscle

" in MedChemExpress (MCE) Product Catalog:
Products (26)

26 Results for "respiratory muscle" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N0677
CAS No.: 786593-06-4
Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways .
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Cat. No.: HY-134575
CAS No.: 54164-50-0
Purity:  99.89%
Target:  

Apoptosis GSK-3

Research Areas:  

Others

C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain .
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Cat. No.: HY-B1209
CAS No.: 519-37-9
Synonyms: 7-(β-Hydroxyethyl)theophylline
Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos .
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Cat. No.: HY-B0771A
CAS No.: 113981-44-5
Synonyms: SCE-2787 hydrochloride
Cefozopran (SCE-2787) hydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran hydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran hydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran hydrochloride can be used for the research of bacterial infections .
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Cat. No.: HY-164027
CAS No.: 2614161-13-4
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Metabolic Disease Cancer

MyoMed 205 is an orally active muscle ring finger protein 1 (MuRF1) inhibitor. MyoMed-205 reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity. MyoMed 205 augments muscle performance, attenuates muscle weight loss and alleviates disease-induced weight loss. MyoMed 205 can be used for the research of cancer cachexia, type 2 diabetes mellitus, and heart failure with preserved ejection fraction .
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Cat. No.: HY-I0501
CAS No.: 551-93-9
Synonyms: o-aminoacetophenone
2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .
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Cat. No.: HY-I0501R
CAS No.: 551-93-9
Synonyms: o-aminoacetophenone (Standard)
2'-Aminoacetophenone (Standard) is the analytical standard of 2'-Aminoacetophenone. This product is intended for research and analytical applications. 2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .
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Cat. No.: HY-119985
CAS No.: 76596-57-1
Synonyms: Z 1170
Target:  

Adrenergic Receptor

Research Areas:  

Others

Broxaterol (Z 1170) is the an agonist of β2 adrenergic receptor that affects the smooth muscle receptors in the body. Broxaterol plays an important role in respiratory disease .
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Cat. No.: HY-B0771
CAS No.: 113359-04-9
Synonyms: SCE-2787
Cefozopran (SCE-2787) is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran can be used for the research of bacterial infections .
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Cat. No.: HY-P5769
CAS No.: 121377-67-1
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus). Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases .
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Cat. No.: HY-105762
CAS No.: 314-35-2
Synonyms: Etamiphylline
Target:  

Others

Research Areas:  

Inflammation/Immunology

Etamiphyllin (Etamiphylline) is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis .
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Cat. No.: HY-105762A
CAS No.: 19326-29-5
Synonyms: Etamiphylline camsylate
Target:  

Others

Research Areas:  

Inflammation/Immunology

Etamiphyllin (Etamiphylline) camsylate is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis .
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Cat. No.: HY-122548
CAS No.: 29025-14-7
Target:  

mAChR

Research Areas:  

Endocrinology

Butropium bromide is a competitive mAChR antagonist. Butropium bromide blocks acetylcholine-mediated glandular secretion and muscle contraction signals, suppressing salivary gland secretion and respiratory smooth muscle spasms. Butropium bromide is promising for research of excessive salivation .
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Cat. No.: HY-121020
CAS No.: 83162-82-7
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS) .
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Cat. No.: HY-N6609
CAS No.: 6801-40-7
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .
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Cat. No.: HY-106908
CAS No.: 141184-34-1
Synonyms: WAY-PDA 641
Research Areas:  

Inflammation/Immunology

WAY-PDA 641 is a potent and preferential PDE-IV inhibitor, with an IC50 of 0.42 μM for canine trachealis PDE-IV. WAY-PDA 641 induces respiratory muscle relaxation and bronchodilation .
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Cat. No.: HY-119146
CAS No.: 31352-82-6
Synonyms: CI-716 free base
Target:  

Drug Derivative

Research Areas:  

Neurological Disease

Zolazepam (CI-716 free base) is a benzodiazepine derivative with anxiolytic and anticonvulsant properties. Zolazepam combined with Tiletamine causes a decrease in ventilation, resulting in the development of respiratory acidosis. Zolazepam can be used as sedative and muscle relaxants .
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Cat. No.: HY-12980A
CAS No.: 945905-37-3
Synonyms: GSK961081 Succinate; TD-5959 Succinate
Research Areas:  

Neurological Disease

Batefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD) .
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Cat. No.: HY-158332
CAS No.: 72131-33-0
Purity:  99.29%
Synonyms: SKF-95587; BM-13177
Research Areas:  

Cardiovascular Disease

Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor). Sulotroban exhibits inhibitory activity against carbocyclic thromboxane A2- and endoperoxide-induced vasoconstrictor. Sulotroban inhibits platelets aggregation .
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Cat. No.: HY-14915A
CAS No.: 194785-31-4
Synonyms: MN-221; KUR-1246
Target:  

Adrenergic Receptor

Research Areas:  

Inflammation/Immunology

Bedoradrine (MN-221) sulfate is a highly selective β2-adrenergic receptor agonist. Bedoradrine sulfate can effectively relieve airway spasm, dilate airway smooth muscle cells, reduce airway inflammation, and thus improve respiratory function. Bedoradrine sulfate can be used in research on asthma .
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