29025-14-7
Chemical Structure
Butropium bromide
- CAS No.: 29025-14-7
- Formula:C28H38BrNO4
- Molecular Weight:532.51
IUPAC Name: (1R,3s,5S)-8-(4-butoxybenzyl)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
InChIKey: JABDOYKGZCPHPX-MEWGDAIISA-M
SMILES: [H][C@]12C[C@H](C[C@]([N+]2(C)CC3=CC=C(C=C3)OCCCC)([H])CC1)OC(C(CO)C4=CC=CC=C4)=O.[Br-]
Biological Activity: Butropium bromide is a competitive mAChR antagonist. Butropium bromide blocks acetylcholine-mediated glandular secretion and muscle contraction signals, suppressing salivary gland secretion and respiratory smooth muscle spasms. Butropium bromide is promising for research of excessive salivation[1][2].
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Butropium bromide | Butropium bromide is a competitive mAChR antagonist. Butropium bromide blocks acetylcholine-mediated glandular secretion and muscle contraction signals, suppressing salivary gland secretion and respiratory smooth muscle spasms. Butropium bromide is promising for research of excessive salivation. | |||||||||||||||||||||
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References
- [1]. Sakamoto Y, et al. The Effect of Butropium Bromide as a Premedication for Depression of Salivation on Endoscopic Examination Using Double Blind Technique[J]. Nihon Kikan Shokudoka Gakkai Kaiho, 1977, 28(1): 20-24.
- [2]. Chiba S. Effect of N-(4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation[J]. Japanese Heart Journal, 1980, 21(5): 753-759.
