4 Results for "

synaptic integrity

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "synaptic integrity" in MCE Product Catalog:

1
Homogentisic acid
Homogentisic acid
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1 Cited Publications
Cat. No.: HY-113283
CAS No.: 451-13-8
Purity:  99.46%
Category:  

Other disease Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin

Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .
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3-Carene
3-Carene
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Cat. No.: HY-N6663
CAS No.: 13466-78-9
Category:  

Other Monoterpenes Plant Terpenoids Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Mitochondrial Metabolism Bacterial GABA Receptor Succinate Dehydrogenase Malate Dehydrogenase (MDH) Pyruvate Kinase

3-Carene is an orally active TCA cycle enzyme inhibitor. 3-Carene inhibits succinate dehydrogenase and malate dehydrogenase as well as pyruvate kinase, disrupting energy metabolism. 3-Carene disrupts cell wall and cell membrane integrity, leading to potassium ion leakage, protein leakage, membrane depolarization, ATP depletion, morphological disruption, and cell lysis. 3-Carene interferes with amino acid metabolism, pantothenate and CoA biosynthesis, purine and pyrimidine metabolism, and aminoacyl-tRNA biosynthesis. 3-Carene enhances GABA receptor-mediated synaptic responses. 3-Carene can be used in research on bacterial infections, inflammation, anxiety, and sleep disorders .
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3-Carene (Standard)
3-Carene (Standard)
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Cat. No.: HY-N6663R
CAS No.: 13466-78-9
Category:  

Other Monoterpenes Plant Terpenoids Other Families Extract

Target:  

Reference Standards Mitochondrial Metabolism Bacterial GABA Receptor Succinate Dehydrogenase Malate Dehydrogenase (MDH) Pyruvate Kinase

3-Carene (Standard) is the analytical standard of 3-Carene (HY-N6663). This product is intended for research and analytical applications. 3-Carene is an orally active TCA cycle enzyme inhibitor. 3-Carene inhibits succinate dehydrogenase and malate dehydrogenase as well as pyruvate kinase, disrupting energy metabolism. 3-Carene disrupts cell wall and cell membrane integrity, leading to potassium ion leakage, protein leakage, membrane depolarization, ATP depletion, morphological disruption, and cell lysis. 3-Carene interferes with amino acid metabolism, pantothenate and CoA biosynthesis, purine and pyrimidine metabolism, and aminoacyl-tRNA biosynthesis. 3-Carene enhances GABA receptor-mediated synaptic responses. 3-Carene can be used in research on bacterial infections, inflammation, anxiety, and sleep disorders .
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COX-2/HDAC6-IN-1
COX-2/HDAC6-IN-1
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Cat. No.: HY-181926
Target:  

COX HDAC Microtubule/Tubulin Interleukin Related Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

COX-2/HDAC6-IN-1 (Compound 11e) is a dual COX-2 and HDAC6 inhibitor, with an IC50 of 0.12 μM against HDAC6 and an IC50 of 0.66 μM against COX-2. COX-2/HDAC6-IN-1 enhances the acetylation level of α-tubulin, regulates epigenetic gene expression, and inhibits the expression of pro-inflammatory mediators (COX-2, IL-1β, IL-6 and TNF-α). COX-2/HDAC6-IN-1 promotes Amyloid-β clearance and reduces excessive phosphorylation of Tau protein. COX-2/HDAC6-IN-1 maintains neuronal morphology by stabilizing MAP2, protects synaptic integrity by regulating synapsin, and restores the expression of memory-related genes. COX-2/HDAC6-IN-1 possesses neuroprotective activity and improves learning and memory abilities in Scopolamine (HY-N0296)-induced Alzheimer's disease mouse models. COX-2/HDAC6-IN-1 is applicable to research related to Alzheimer's disease .
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