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Results for "

transferrin receptors

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

1

Fluorescent Dyes

10

Biochemical Assay Reagents

6

Peptides

8

Inhibitory Antibodies

8

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P9999
    Trontinemab

    RG6102; RO-7126209

    		 Amyloid-β Neurological Disease
    Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
    Trontinemab
  • HY-P3267
    Holo-Bovine Transferrin
    2 Publications Verification

    		 Transferrin Receptor Others
    Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
    Holo-Bovine Transferrin
  • HY-P991047
    Anti-CD71/TfR1 Antibody

    JR-141 antibody (uncoupled from iduronate 2-sulfatase)

    		 Transferrin Receptor Neurological Disease Cancer
    Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
    Anti-CD71/TfR1 Antibody
  • HY-P990051
    Delpacibart

    AOC-1001 Antibody; AOC-1044 Antibody

    		 Transferrin Receptor Neurological Disease Inflammation/Immunology
    Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
    Delpacibart
  • HY-P99797
    Pabinafusp alfa

    JR-141

    		 Transferrin Receptor Neurological Disease
    Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
    Pabinafusp alfa
  • HY-P3267A
    Apo-Bovine Transferrin

    		Ferroportin Transferrin Receptor Neurological Disease
    Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
    Apo-Bovine Transferrin
  • HY-P2297
    TfR-T12

    		Transferrin Receptor Metabolic Disease
    TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
    TfR-T12
  • HY-P11099
    Cys-LT7

    		Transferrin Receptor Neurological Disease Cancer
    Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .
    Cys-LT7
  • HY-159569
    TfR-1-IN-1
    1 Publications Verification

    		 Transferrin Receptor Ferroptosis Apoptosis Necroptosis Cancer
    TfR-1-IN-1 is a transferrin receptor-1 (TfR-1) inhibitor with tumor cell-specific activity. TfR-1-IN-1 reduces TfR-1 expression, impairs mitochondrial function, induces cell apoptosis, necroptosis and ferroptosis, and increases intracellular iron (II) levels. TfR-1-IN-1 decreases the metabolic activity of cancer cells. TfR-1-IN-1 can be used for the research of ovarian cancer, breast cancer and acute myeloid leukemia .
    TfR-1-IN-1
  • HY-D2426
    Cy3-Transferrin

    		Fluorescent Dye Transferrin Receptor Cardiovascular Disease
    Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .
    Cy3-Transferrin
  • HY-P2314
    HAIYPRH hydrochloride

    		Transferrin Receptor Cancer
    HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .
    HAIYPRH hydrochloride
  • HY-P991381
    JST-TfR09

    PPMX-T003

    		 Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis Cancer
    JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .
    JST-TfR09
  • HY-P990130
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)

    		Transferrin Receptor Neurological Disease
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)
  • HY-P990856
    Anti-CD71 Antibody (OKT-9)

    		Transferrin Receptor Cancer
    Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .
    Anti-CD71 Antibody (OKT-9)
  • HY-P10323
    T7 Peptide

    Tumstatin (74-98), human

    		 Integrin FAK mTOR Apoptosis Cancer
    T7 Peptide is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
    T7 Peptide
  • HY-173444
    HDAC11-IN-3

    		HDAC Transferrin Receptor Apoptosis Ferroptosis Cancer
    HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research .
    HDAC11-IN-3
  • HY-177564
    Delpacibart zotadirsen

    Del-zota; AOC 1044

    		 Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor Dystrophin Neurological Disease
    Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .
    Delpacibart zotadirsen
  • HY-P10323A
    T7 Peptide TFA

    Tumstatin (74-98), human TFA

    		 Integrin FAK mTOR Apoptosis Cancer
    T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide TFA inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide TFA induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide TFA is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
    T7 Peptide TFA
  • HY-P990791
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)

    		Transferrin Receptor Infection Inflammation/Immunology Cancer
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)
  • HY-NP170
    Holo Transferrin (Bovine)

    HTF (Bovine)

    		 Biochemical Assay Reagents Metabolic Disease
    Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
    Holo Transferrin (Bovine)
  • HY-P2297A
    TfR-T12 TFA

    		Transferrin Receptor Metabolic Disease
    TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
    TfR-T12 TFA
  • HY-172691
    DSPE-PEG5000-THRPPMWSPVWP

    		Liposome Cancer
    DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
    DSPE-PEG5000-THRPPMWSPVWP
  • HY-172690
    DSPE-PEG2000-THRPPMWSPVWP

    		Liposome Cancer
    DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
    DSPE-PEG2000-THRPPMWSPVWP
  • HY-172723A
    DSPE-PEG3400-T7

    		Liposome Cancer
    DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .
    DSPE-PEG3400-T7
  • HY-172724
    DSPE-PEG5000-T7

    		Liposome Cancer
    DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .
    DSPE-PEG5000-T7
  • HY-172722
    DSPE-PEG1000-T7

    		Liposome Cancer
    DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .
    DSPE-PEG1000-T7
  • HY-115832
    Ap44mSe

    		Transferrin Receptor Cancer
    Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .
    Ap44mSe
  • HY-B0824A
    (1R)-cis-Bifenthrin

    		Autophagy Others
    (1R)-cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R)-cis-Bifenthrin has a significant impact on the motor function of ParKin-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R)-cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R)-cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R)-cis-Bifenthrin has a lower binding energy with transferrin and transferrin receptor 2, showing stronger interactions. The biological effects of (1R)-cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways .
    (1R)-cis-Bifenthrin
  • HY-185100
    Waz sodium

    		Transferrin Receptor Cancer
    Waz sodium is an anti-transferrin receptor aptamer.
    Waz sodium
  • HY-172690A
    DSPE-PEG3400-THRPPMWSPVWP

    		Liposome Cancer
    DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
    DSPE-PEG3400-THRPPMWSPVWP
  • HY-172689
    DSPE-PEG1000-THRPPMWSPVWP

    		Liposome Cancer
    DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
    DSPE-PEG1000-THRPPMWSPVWP
  • HY-181953
    STIM1-TFR1-IN-1

    		Transferrin Receptor Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Neurological Disease
    STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 (STIM1)-transferrin receptor 1 (TFR1) protein complex inhibitor with a Kd of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis, lipid peroxidation and ROS production, enhances glutathione peroxidase 4 (GPX4) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective
    effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage .
    STIM1-TFR1-IN-1
  • HY-147262
    Etedesiran

    		Antibody-Oligonucleotide Conjugates (AOCs) Small Interfering RNA (siRNA) Neurological Disease
    Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .
    Etedesiran

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