trifluoroacetic acid

By Targets:	Amino Acid Derivatives (3) Biochemical Assay Reagents (4) Complement System (1) Endogenous Metabolite (1) Histone Acetyltransferase (1) IKK (1) Isotope-Labeled Compounds (3) Mitochondrial Metabolism (1) Molecular Glues (1) Neuropeptide Y Receptor (1) NF-κB (1) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) PROTACs (1) Reference Standards (1) WDR5 (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)
Click Chemistry:	Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1353

Di-tert-butyl dicarbonate	Biochemical Assay Reagents	Others Metabolic Disease
Di-tert-butyl dicarbonate (tBOC) is a covalent modification agent for hydroxyl groups (-OH) on the chitosan molecular chain. Di-tert-butyl dicarbonate selectively modifies chitosan and stabilizes the material structure through hydrophobic encapsulation. Di-tert-butyl dicarbonate reacts with the -OH groups of chitosan to form a hydrophobic layer, and in conjunction with triethylamine (TEA), removes trifluoroacetic acid (TFA) salts produced during the electrospinning process, preserving the nanofiber structure and high porosity of the membrane, and improving the material's cytocompatibility and mineralization-promoting ability. Di-tert-butyl dicarbonate can be used in research in the field of guided bone regeneration (GBR) .

HY-134222A

N-Acetylserine N-Acetyl-L-serine	Endogenous Metabolite Complement System	Others
N-Acetylserine (N-Acetyl-L-serine) is a complement pathway modulator targeting activated third complement protein (C3b) and an amino-terminal residue (an N-terminal acetylation modification group). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins; deblocking is achievable through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification .

HY-W017049S

Sodium trifluoroacetate-13C2 trifluoroacetic acid-13C2 sodium	Isotope-Labeled Compounds	Others
Sodium trifluoroacetate- ¹³C₂ (Trifluoroacetic acid- ¹³C₂ sodium) is the ¹³C labeled isotope of Sodium trifluoroacetate .

HY-W754811

Trifluoroacetic acid-13C sodium	Isotope-Labeled Compounds	Others
Trifluoroacetic acid- ¹³C sodium is the ¹³C labeled isotope of Trifluoroacetic acid sodium .

HY-W105853

Ammonium trifluoroacetate trifluoroacetic acid amine	Biochemical Assay Reagents	Others
Ammonium trifluoroacetate is an additive for regulating and calibrating new liquid/mass spectrometry systems .

HY-169955A

WIZ degrader 8 TFA	Histone Acetyltransferase Molecular Glues	Cardiovascular Disease
WIZ degrader 8 (TFA) is the trifluoroacetic acid of WIZ degrader 8 (HY-169955). WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease .

HY-16386A

PENAO TFA	Mitochondrial Metabolism	Cancer
PENAO TFA is the trifluoroacetic acid of PENAO (HY-16386). PENAO is a potent tumour cell mitochondrial toxin. PENAO inactivates tumor cell mitochondria by targeting inner-membrane adenine nucleotide transferase .

HY-P11291A

NNC0165-1273 TFA	Neuropeptide Y Receptor	Metabolic Disease
NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291). NNC0165-1273 is an analog of gut hormone peptide YY (PYY_3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research .

HY-164732

Fmoc-Lys(DOTA)-OH	Amino Acid Derivatives Biochemical Assay Reagents	Others
Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research .

HY-W013201

*(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic* acid (1:1)**	Amino Acid Derivatives	Others
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-W017049R

Sodium trifluoroacetate (Standard) trifluoroacetic acid sodium (Standard)	Reference Standards
Sodium 2,2,2-trifluoroacetate (Standard) is the analytical standard of Sodium 2,2,2-trifluoroacetate. This product is intended for research and analytical applications.

HY-109166

Amdakefalin	Opioid Receptor	Neurological Disease
Amdakefalin is a μ and δ opioid receptors agonist with analgesic effects .

HY-150400A

XF056-132	PROTACs WDR5	Others
XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).

HY-183002

N6-(3-Azidopropanoyl)-N2-(tert-butoxycarbonyl)-L-lysine	Biochemical Assay Reagents Amino Acid Derivatives	Others
N6-(3-Azidopropanoyl)-N2-(tert-butoxycarbonyl)-L-lysine is an L-lysine (HY-N0469) derivative and an azide molecule used for click chemistry conjugation .

Cat. No.	Product Name	Type

HY-W105853

Ammonium trifluoroacetate trifluoroacetic acid amine	Biochemical Assay Reagents
Ammonium trifluoroacetate is an additive for regulating and calibrating new liquid/mass spectrometry systems .

Cat. No.	Product Name	Target	Research Area

HY-P11291A

NNC0165-1273 TFA	Neuropeptide Y Receptor	Metabolic Disease
NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291). NNC0165-1273 is an analog of gut hormone peptide YY (PYY_3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research .

HY-W013201

*(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic* acid (1:1)**	Amino Acid Derivatives	Others
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA	Isotope-Labeled Compounds Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

HY-204478A

Ac-KVPL-CMK TFA	Peptides	Cancer
Ac-KVPL-CMK TFA is the trifluoroacetic acid of Ac-KVPL-CMK (HY-204478). Ac-KVPL-CMK is an inhibitor that specifically targets Granzyme M (GrM). Ac-KVPL-CMK significantly inhibits GrM-mediated tumor cell death. Ac-KVPL-CMK reduces the cytotoxic activity of LAK cells against HeLa cells. Ac-KVPL-CMK can be used for the study of cancer .

HY-109166

Amdakefalin	Opioid Receptor	Neurological Disease
Amdakefalin is a μ and δ opioid receptors agonist with analgesic effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134222A

N-Acetylserine N-Acetyl-L-serine	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Complement System
N-Acetylserine (N-Acetyl-L-serine) is a complement pathway modulator targeting activated third complement protein (C3b) and an amino-terminal residue (an N-terminal acetylation modification group). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins; deblocking is achievable through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification .

Cat. No.	Product Name	Chemical Structure

HY-W017049S

Sodium trifluoroacetate-13C2
Sodium trifluoroacetate- ¹³C₂ (Trifluoroacetic acid- ¹³C₂ sodium) is the ¹³C labeled isotope of Sodium trifluoroacetate .

HY-W754811

Trifluoroacetic acid-13C sodium
Trifluoroacetic acid- ¹³C sodium is the ¹³C labeled isotope of Trifluoroacetic acid sodium .

HY-106224AS1

Orexin A-13C18,15N3 (human, rat, mouse) TFA
Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Orexin A-13C18,15N3 (human, rat, mouse) TFA

Orexin A- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse) ((Hypocretin-1- ¹³C₁₈, ¹⁵N₃ (human, rat, mouse)) TFA is the ¹³C- and ¹⁵N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .

Cat. No.	Product Name		Classification

HY-183002

N6-(3-Azidopropanoyl)-N2-(tert-butoxycarbonyl)-L-lysine		Azide
N6-(3-Azidopropanoyl)-N2-(tert-butoxycarbonyl)-L-lysine is an L-lysine (HY-N0469) derivative and an azide molecule used for click chemistry conjugation .

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