38 Results for "

uPAR

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "uPAR" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-111192
CAS No.: 892243-35-5
Purity:  ≥98.0%
Target:  

Ser/Thr Protease

Research Areas:  

Cancer

IPR-803 is a potent inhibitor of the uPAR·uPA protein-protein interaction (PPI). IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P2230
CAS No.: 220334-14-5
Synonyms: A6 Peptide
Target:  

PAI-1

Research Areas:  

Cancer

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .
loading...
    loading...
Cat. No.: HY-P11446
CAS No.: 254729-66-3
Research Areas:  

Cancer

AE105 is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 binds tightly to the uPA-binding cavity of uPAR. AE105 can be used for the study of cancer .
loading...
    loading...
Cat. No.: HY-P990552A

Target:  

PAI-1 Integrin

Research Areas:  

Cancer

huATN-658 is an inhibitor that specifically targets the DIII domain of human urokinase plasminogen activator receptor (uPAR). huATN-658 neutralizes uPAR function by blocking the interaction between uPAR and integrins, without interfering with the binding of uPA or vitronectin to uPAR. huATN-658 inhibits the proliferation and invasion of breast cancer cells, slows the growth of primary breast tumors, reduces breast cancer-induced bone lesions and decreases osteoclast activity. huATN-658 also alters the gene expression of the TGF-β receptor complex signaling pathway. huATN-658 exerts synergistic anticancer effects when combined with Zoledronic Acid (HY-13777), and does not cause physiological or behavioral abnormalities in immunodeficient mice. huATN-658 can be used in research related to breast cancer, metastatic breast cancer and breast cancer-induced bone disease .
loading...
    loading...
Cat. No.: HY-P5018
CAS No.: 1820563-84-5
NOTA-AE105 is a PET ligand for the urokinase-type plasminogen activator receptor (uPAR). NOTA-AE105 can be radiolabeled with 64Cu and 68Ga. Images of 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 demonstrate high contrast and clear tumor delineation. NOTA-AE105 can be used in the synthesis of radionuclide-conjugated compounds (RDCs) .
loading...
    loading...
Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: uPARANT
Cenupatide (UPARANT) is a uPAR and FPR antagonist with anti-angiogenic, anti-inflammatory, and vascular barrier regulatory activities, as well as high stability and resistance to enzymatic degradation in blood/plasma. Cenupatide blocks the uPAR-FPR interaction, reduces VEGF-induced phosphorylation levels of AKT, VEGFR-2, STAT3, JNK, p38 MAPK, ERK1/2, and NF-κB p65, and inhibits αvβ3 integrin activation. Cenupatide suppresses endothelial cell migration, invasion, tube formation, and angiogenic signaling pathways, restores tight junctions and blood-retinal barrier integrity, reduces pro-inflammatory marker levels, and inhibits apoptosis. Cenupatide reduces retinal neovascularization, renal fibrosis, and vascular leakage, and restores visual function in preclinical models. Cenupatide is applicable to research related to retinopathy, diabetic complications, ocular diseases, cancer, and inflammatory diseases .
loading...
    loading...
Cat. No.: HY-132187
CAS No.: 1670-26-4
Purity:  99.50%
Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a Kd of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes .
loading...
    loading...
Cat. No.: HY-RS10648
Research Areas:  

Others

PLAUR Human Pre-designed siRNA Set A contains three designed siRNAs for PLAUR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P990552

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

ATN-658 is a mouse-derived IgG antibody expressed in CHO cells that targets PLAUR/uPAR/CD87. ATN-658 contains muIgG1 heavy chain and mκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for ATN-658 can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
loading...
    loading...
Cat. No.: HY-P11023
Target:  

Peptides

E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR). E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research .
loading...
    loading...
Cat. No.: HY-P11446A
Research Areas:  

Cancer

AE105 TFA is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 TFA binds tightly to the uPA-binding cavity of uPAR. AE105 TFA can be used for the study of cancer .
loading...
    loading...
Cat. No.: HY-RS17422
Research Areas:  

Others

Plaur Mouse Pre-designed siRNA Set A contains three designed siRNAs for Plaur gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P11413
CAS No.: 139446-70-1
PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus .
loading...
    loading...
Cat. No.: HY-RS24858
Research Areas:  

Others

Cadm4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cadm4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS23877
Research Areas:  

Others

Plaur Rat Pre-designed siRNA Set A contains three designed siRNAs for Plaur gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P704954
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: U-PAR; uPAR; CD87; PLAUR; MO3; uPAR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P704953
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: U-PAR; uPAR; CD87; PLAUR; MO3; uPAR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P704957
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: U-PAR; uPAR; CD87; PLAUR; MO3; uPAR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P700849
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: U-PAR; uPAR; CD87; PLAUR; MO3; uPAR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P700897
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: U-PAR; uPAR; CD87; PLAUR; MO3; uPAR
Species:  
Source:  
loading...
    loading...