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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
112 Results for "
ubiquitin-specific protease
" in MedChemExpress (MCE) Product Catalog:
Products (112)
112 Results for "ubiquitin-specific protease" in MCE Product Catalog:
507
507 Publications Verification
Synonyms: BAY 11-7821
Target:
Research Areas:
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
28
Target:
Research Areas:
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 μM.
25
25 Cited Publications
Target:
Research Areas:
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM.
18
18 Cited Publications
Cat. No.: HY-17540
CAS No.: 1426944-49-1
Target:
Research Areas:
HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM.
7
7 Cited Publications
Cat. No.: HY-16709
CAS No.: 1381291-36-6
Target:
Research Areas:
USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.
7
Target:
Research Areas:
USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model .
4
4 Cited Publications
Target:
Research Areas:
BAY-805, a chemical probe, is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .
4
4 Cited Publications
Target:
Research Areas:
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
4
4 Cited Publications
Cat. No.: HY-50736
CAS No.: 924296-18-4
Target:
Research Areas:
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8 .
4
4 Cited Publications
Target:
Research Areas:
HBX 41108 is an inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. BX 41108 can be used in cancer and diabetes research .
3
3 Cited Publications
Target:
Research Areas:
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .
3
Research Areas:
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
2
2 Cited Publications
Target:
Research Areas:
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). USP7-IN-3 can be used for research on acute lymphoblastic leukemia .
1
1 Cited Publications
Target:
Research Areas:
FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM .
1
1 Cited Publications
Target:
Research Areas:
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects .
1
1 Cited Publications
Cat. No.: HY-P701431
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP9X; ubiquitin specific Peptidase 9 X-Linked; DFFRX; FAF-X; MRX99; FAF; ubiquitin specific protease 9, X Chromosome (Fat Facets-Like Drosophila); ubiquitin-specific protease 9, X Chromosome; ubiquitin Carboxyl-Terminal Hydrolase 9X; Deubiquitinating Enz
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P702063
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: USP11; ubiquitin specific Peptidase 11; UHX1; ubiquitin Carboxyl-Terminal Hydrolase 11; Deubiquitinating Enzyme 11; ubiquitin Thioesterase 11; ubiquitin Carboxyl-Terminal Hydrolase, X-Linked; ubiquitin-specific Processing protease 11; ubiquitin-specific-P
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701411
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP15; ubiquitin specific Peptidase 15; KIAA0529; UNPH4; ubiquitin-specific-Processing protease 15; ubiquitin Carboxyl-Terminal Hydrolase 15; Deubiquitinating Enzyme 15; ubiquitin Thioesterase 15; ubiquitin specific protease 15; ubiquitin Thiolesterase 15
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P71418
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP14; ubiquitin specific Peptidase 14; TGT; Ubp6; ubiquitin specific Peptidase 14 (TRNA-Guanine Transglycosylase); ubiquitin specific protease 14 (TRNA-Guanine Transglycosylase); ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiqu
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P701447
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP28; ubiquitin specific Peptidase 28; ubiquitin-specific-Processing protease 28; ubiquitin Carboxyl-Terminal Hydrolase 28; Deubiquitinating Enzyme 28; ubiquitin Thioesterase 28; KIAA1515; ubiquitin Carboxyl-Terminal Hydrolase; ubiquitin specific Proteas
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
