2165322-94-9
2165322-94-9
Chemical Structure
USP25/28 inhibitor AZ1
Synonym(s): AZ1
- CAS No.: 2165322-94-9
- Formula:C17H16BrF4NO2
- Molecular Weight:422.21
IUPAC Name: 2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethan-1-ol
InChIKey: ITHSFXDGKQYOED-UHFFFAOYSA-N
SMILES: FC(C1=CC(COC2=CC=C(Br)C=C2CNCCO)=CC=C1F)(F)F
Biological Activity: USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model[1][2].
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USP25/28 inhibitor AZ1 | 98.0% | USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model. | ||||||||||||||||||||
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References
- [1]. Wrigley JD, et al. Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating EnzymeSubfamily. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125. [Content Brief]
- [2]. Xiao-Meng Wang, et al. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nature Cancer volume 1, pages811–825(2020).
Keywords
