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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
voltage sensor
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "voltage sensor" in MCE Product Catalog:
Cat. No.: HY-P10817
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Cat. No.: HY-P10817A
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Cat. No.: HY-P1073
CAS No.: 484598-35-8
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Cat. No.: HY-P11045
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JNJ63955918 is a Nav1.7 closed-state blocker (pIC50 = 8.0). JNJ63955918 binds to the resting/closed state of voltage-gated sodium channels, immobilizing the voltage sensor, thereby preventing activation in a low voltage-dependent manner and causing a depolarizing shift in activation without significantly affecting inactivation. JNJ63955918 can be used for pain research .
Cat. No.: HY-P5916
Synonyms: κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; voltage sensor toxin 3; Peptide F
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Cat. No.: HY-126007
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PF-06526290 is a voltage-gated sodium (Nav) channel modulator with dual activity of enhancing and inhibiting Nav channel conduction. PF-06526290 slows inactivation by binding to the resting state of Nav channels, and exerts inactivation state-dependent inhibition after prolonged depolarization by acting on the voltage sensor of the fourth homologous domain 4 (D4 VSD). PF-06526290 can be used in research on neurological disorders such as epilepsy and autism .
Cat. No.: HY-187364
CAS No.: 3050594-88-9
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TRPV4 antagonist-7 is a potent and selective TRPV4 antagonist with an IC50 of 0.2 nM against human targets. TRPV4 antagonist-7 binds to the voltage-sensor-like domain cavity of TRPV4 and inhibits channel activity through the formation of salt bridges, hydrogen bonds, and edge-to-face π-stacking interactions. TRPV4 antagonist-7 induces phospholipid accumulation in HepG2 C3A cells in vitro with an IC50 of 3.8 μM, and exhibits moderate inhibitory effects on CYP2D6 with an IC50 of 5.1 μM. TRPV4 antagonist-7 dose-dependently inhibits GSK1016790A (HY-19608)-induced bronchoconstriction in rats and cough in guinea pigs. TRPV4 antagonist-7 can be used in studies related to respiratory system diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
