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Cat. No.: HY-P11045

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JNJ63955918

JNJ63955918 is a potent, highly selective, blocked-state Nav1.7 blocking peptide with an IC₅₀ of 8.0 nM. JNJ63955918 can be used in pain research.

For research use only. We do not sell to patients.

Formula: C₁₆₄H₂₅₉N₄₇O₄₄S₈
Molecular Weight:3849.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JNJ63955918 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JNJ63955918 is a potent, highly selective, blocked-state Nav1.7 blocking peptide with an IC₅₀ of 8.0 nM. JNJ63955918 can be used in pain research^[1].

IC₅₀ & Target

h Na_v1.7

8.0 nM (IC₅₀)

All Sodium Channel Isoforms :

Chemical Information

Molecular Weight 3849.62
Formula C₁₆₄H₂₅₉N₄₇O₄₄S₈
Sequence

Gly-Pro-Tyr-Cys-Gln-Lys-Trp-Met-Gln-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Leu (Disulfide bridge: Cys4-Cys18;Cys11-Cys23;Cys17-Cys27)
Sequence Shortening

GPYCQKWMQTCDSERKCCEGMVCRLWCKKKLL (Disulfide bridge:Cys4-Cys18;Cys11-Cys23;Cys17-Cys27)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Flinspach M, et al. Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Sci Rep. 2017 Jan 3;7:39662. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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JNJ63955918

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ63955918 Related Classifications

HY-P11045 Related Classifications