7 Results for "

zebrafish oocyte

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "zebrafish oocyte" in MCE Product Catalog:

3
NBI-31772
NBI-31772
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3 Cited Publications
Art. -Nr.: HY-110135
CAS. Nr.: 374620-70-9
Reinheit:  98.88%
Target:  

IGF-1R

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology

NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation .
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Isotocin
Isotocin
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Art. -Nr.: HY-P4184
CAS. Nr.: 550-21-0
Synonyms: (Ser4,Ile8)-Oxytocin
Target:  

Endogenous Metabolite Aminopeptidase

Forschungsgebiete:  

Neurological Disease

Isotocin is the homologue of mammalian oxytocin in teleost fish, belonging to the category of neurotransmitters/neuromodulators and peripheral hormones. Isotocin exerts biological effects by binding to its homologous isotocin receptor (with EC50 = 1.58e-10 mol/L in gilthead seabream) and specific G-protein-coupled receptor subtypes. Isotocin promotes paternal behavior in cichlids, regulates the expression of Foxi3a and P63, thereby controlling the differentiation of ionocyte progenitor cells and the proliferation of epidermal stem cells, and modulates whole-body ion content in zebrafish embryos. Isotocin regulates social and reproductive behaviors, synchronizes the reproductive cycles of teleost fish, and its neuronal phenotypes can be used to classify the types of reproductive systems in cichlids .
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Isopsoralenoside
Isopsoralenoside
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Art. -Nr.: HY-N7504
CAS. Nr.: 905954-18-9
Category:  

Infection Leguminosae Ketones, Aldehydes, Acids Metabolic Disease Psoralea corylifolia L. Plants Disease Research Fields

Target:  

Bacterial Reactive Oxygen Species (ROS)

Isopsoralenoside is a benzofuran glycoside and coumarin-derived compound. Isopsoralenoside exists in the dried mature fruits of Psoralea corylifolia L., and acts as a metabolite precursor, toxicant and inducer, with estrogen-like, osteoblast proliferation-promoting, anti-tumor and antibacterial activities. Isopsoralenoside can be deglycosylated by intestinal flora to form isopsoralen. Isopsoralenoside induces oocyte death in zebrafish, activates oxidative stress and cell death-related pathways in zebrafish follicles, and is the main effector substance responsible for the reproductive toxicity induced by Fructus Psoraleae. Isopsoralenoside can be used in studies related to reproductive toxicity (ovarian dysfunction, follicular atresia, impaired fertility) .
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DTP348
DTP348
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Art. -Nr.: HY-120367
CAS. Nr.: 1383370-92-0
Target:  

Carbonic Anhydrase

Forschungsgebiete:  

Cancer

DTP348 is an inhibitor for carbonic anhydrase IX with a Ki of 8.3 nM in vitro and an IC50 of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with LD50 of 3.5 mM. DTP348 can be used in the anti-cancer research .
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NBI-31772 (Standard)
NBI-31772 (Standard)
0 Images
Art. -Nr.: HY-110135R
CAS. Nr.: 374620-70-9
Target:  

IGF-1R

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology

NBI-31772 (Standard) is the analytical standard of NBI-31772. This product is intended for research and analytical applications. NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation .
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Isotocin acetate
Isotocin acetate
0 Images
Art. -Nr.: HY-P4184A
Synonyms: (Ser4,Ile8)-Oxytocin acetate
Target:  

Endogenous Metabolite Aminopeptidase

Forschungsgebiete:  

Neurological Disease

Isotocin acetate is the homologue of mammalian oxytocin in teleost fish, belonging to the category of neurotransmitters/neuromodulators and peripheral hormones. Isotocin acetate exerts biological effects by binding to its homologous Isotocin acetate receptor (with EC50 = 1.58e-10 mol/L in gilthead seabream) and specific G-protein-coupled receptor subtypes. Isotocin acetate promotes paternal behavior in cichlids, regulates the expression of Foxi3a and P63, thereby controlling the differentiation of ionocyte progenitor cells and the proliferation of epidermal stem cells, and modulates whole-body ion content in zebrafish embryos. Isotocin acetate regulates social and reproductive behaviors, synchronizes the reproductive cycles of teleost fish, and its neuronal phenotypes can be used to classify the types of reproductive systems in cichlids .
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PNU-142586 sodium
PNU-142586 sodium
0 Images
Art. -Nr.: HY-W654323
CAS. Nr.: 2468637-62-7
Target:  

Topoisomerase Drug Metabolite

Forschungsgebiete:  

Others

PNU-142586 sodiu) is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism .
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