(-)-Secoisolariciresinol 4-O-β-D-glucopyranoside
(-)-Secoisolariciresinol 4-O-β-D-glucopyranoside is a lignan that can be found in the roots and rhizomes of Valeriana amurensis. (-)-Secoisolariciresinol 4-O-β-D-glucopyranoside shows no significant neuroprotective effect against Aβ1-42-induced injury to neuronal cells.
For research use only. We do not sell to patients.
- CAS No.: 129102-89-2
- Formula: C26H36O11
- Molecular Weight:524.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(-)-Secoisolariciresinol 4-O-β-D-glucopyranoside (compound 7) (5-25 μM; 4-24 h) shows no significant direct effects on uninjured PC12 cells, and does not exert marked neuroprotective activity against Aβ1-42-induced injury in PC12 cells at these concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:rat pheochromocytoma (PC12) cells
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Concentration:5 μM (24 h incubation with uninjured cells; 4 h pretreatment before Aβ1-42 exposure); 12.5 μM (24 h incubation with uninjured cells; 4 h pretreatment before Aβ1-42 exposure); 25 μM (24 h incubation with uninjured cells; 4 h pretreatment before Aβ1-42 exposure)
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Incubation Time:24 h (uninjured cells incubation); 4 h (pretreatment before Aβ1-42 exposure), followed by 20 h Aβ1-42 treatment
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Result:Caused no significant change in cell viability or LDH release when incubated with uninjured PC12 cells for 24 h at 5, 12.5, or 25 μM.
Did not produce a marked increase in cell viability or reduction in LDH release relative to the model group when used as a 4 h pretreatment before Aβ1-42-induced injury at 5, 12.5, or 25 μM.
Chemical Information
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CAS No. 129102-89-2
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Molecular Weight 524.56
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Formula C26H36O11
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SMILES
COC(C=C(C=C1)C[C@@H](CO)[C@H](CO)CC2=CC(OC)=C(C=C2)O)=C1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Secoisolariciresinol 4-O-β-D-glucopyranoside Related Classifications
HY-N20640 Related Classifications
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