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Cat. No.: HY-184799

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sEH-IN-25

sEH-IN-25 is an orally active soluble epoxide hydrolase (epoxide hydrolase) inhibitor, with an IC₅₀ of 0.5 nM against human sEH and an IC₅₀ of 2 nM against rat sEH. sEH-IN-25 can be used in the research of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 1141896-04-9
Formula: C₁₉H₂₂BrF₃N₆O₂
Molecular Weight:503.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

sEH-IN-25 Chemical Structure

CAS No.: 1141896-04-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Lipid Metabolism

sEH-IN-25 potently inhibits soluble epoxide hydrolase activity in human embryonic kidney cells overexpressing human sEH with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	CL_plasma	T_1/2	V_dss	Bioavailability
Rat^[1]	2.0 mg/kg	i.v.	/	12 mL/min/kg	4.6 h	2.1 L/kg	100 %
Rat^[1]	0.2 mg/kg	p.o.	8 ng/mL	/	/	/	/
Rat^[1]	2.0 mg/kg	p.o.	112 ng/mL	/	/	/	/
Rat^[1]	20 mg/kg	p.o.	750 ng/mL	/	/	/	/

Chemical Information

CAS No. 1141896-04-9
Molecular Weight 503.32
Formula C₁₉H₂₂BrF₃N₆O₂
SMILES

O=C(C1CCN(CC1)C2=NC(NC)=NC(C)=N2)NCC3=CC=C(C=C3OC(F)(F)F)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thalji RK, et al. Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorganic & medicinal chemistry letters. 2013 Jun 15;23(12):3584-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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