Vrk1 - vaccinia related kinase 1 Gene

Also Known as 51PK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22367

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Vrk1 Products (6)

mRNA Protein Name
NM_001029843.2 NP_001025014.1 serine/threonine-protein kinase VRK1 isoform b
NM_001029844.2 NP_001025015.1 serine/threonine-protein kinase VRK1 isoform c
NM_001364365.1 NP_001351294.1 serine/threonine-protein kinase VRK1 isoform c
NM_001364367.1 NP_001351296.1 serine/threonine-protein kinase VRK1 isoform a
NM_001364368.1 NP_001351297.1 serine/threonine-protein kinase VRK1 isoform d
NM_011705.4 NP_035835.1 serine/threonine-protein kinase VRK1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14645249 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
14645249 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
14645249 MGI
involved in regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
25609612 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14645249 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase VRK1

  • serine/threonine-protein kinase 51PK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126542 VRK-IN-1 Inhibitor 99.47% Unkown
HY-158975 VRK1/CK1-IN-1 Inhibitor 98.69% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vrk1 NCBI NCBI:7443