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Cat. No.: HY-117515

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YLT205

YLT205 is an anticancer agent and induces cell apoptosis. YLT205 inhibits tumor growth in vivo and in vitro.

For research use only. We do not sell to patients.

CAS No.: 1316196-63-0
Formula: C₁₆H₁₂BrClN₄O₂S₂
Molecular Weight:471.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

YLT205 Chemical Structure

CAS No.: 1316196-63-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

YLT205 is an anticancer agent and induces cell apoptosis. YLT205 inhibits tumor growth in vivo and in vitro^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	20 nM Compound: 159a	Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 4 days by MTT assay Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 4 days by MTT assay	[PMID: 31926469]
A549	IC₅₀	44 nM Compound: 159a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 4 days by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 4 days by MTT assay	[PMID: 31926469]
HepG2	IC₅₀	48 nM Compound: 159a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 4 days by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 4 days by MTT assay	[PMID: 31926469]
SW-620	IC₅₀	4.3 nM Compound: 159a	Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 4 days by MTT assay Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 4 days by MTT assay	[PMID: 31926469]

Chemical Information

CAS No. 1316196-63-0
Molecular Weight 471.78
Formula C₁₆H₁₂BrClN₄O₂S₂
SMILES

O=C(CCl)NC1=CC2=C(N=C(SCC(NC3=NC=C(C=C3)Br)=O)S2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Y, et al. A novel small-molecule YLT205 induces apoptosis in human colorectal cells via mitochondrial apoptosis pathway in vitro and inhibits tumor growth in vivo. Cell Physiol Biochem. 2014;33(4):933-944. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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