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Cat. No.: HY-171959

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SHP2-IN-39

SHP2-IN-39 (Example 63) is an inhibitor of SHP2 with an IC₅₀ of 0.007 μM. SHP2-IN-39 can be used in the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1801764-98-6
Formula: C₁₇H₂₀Cl₂N₆OS
Molecular Weight:427.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SHP2-IN-39 Chemical Structure

CAS No.: 1801764-98-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SHP2-IN-39 (Example 63) is an inhibitor of SHP2 with an IC₅₀ of 0.007 μM. SHP2-IN-39 can be used in the research of cancer^[1].

Chemical Information

CAS No. 1801764-98-6
Molecular Weight 427.35
Formula C₁₇H₂₀Cl₂N₆OS
SMILES

N[C@H]1C2(COC1)CCN(C3=NC(N)=C(N=C3)SC4=CC=NC(Cl)=C4Cl)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christine Hiu-Tung Chen, et al. N-azaspirocycloalkane substituted n-heteroaryl compounds and compositions for inhibiting the activity of shp2. WO2015107495A1. 2015-07-23.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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