2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. SM-360320

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

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SM-360320

SM-360320 構造式

CAS 番号 : 226907-52-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 572 在庫あり
Solution
10 mM * 1 mL in DMSO USD 572 在庫あり
Solid
1 mg $250 在庫あり
5 mg $520 在庫あり
10 mg $800 在庫あり
25 mg $1400 在庫あり
50 mg $2100 在庫あり
100 mg $3000 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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SM-360320 関連抗体

Top Publications Citing Use of Products

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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製品説明

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
1.17 μM
Compound: SM360320
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
[PMID: 32001135]
HEK293 EC50
399.4 nM
Compound: 3
Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
[PMID: 20232824]
Huh-7 EC50
30 nM
Compound: BHMA
Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay
Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay
[PMID: 20028817]
PBMC EC50
0.14 μM
Compound: 4, SM360320
Induction of IFNalpha production in human PBMC
Induction of IFNalpha production in human PBMC
[PMID: 16784848]
分子量

315.33

分子式

C15H17N5O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (396.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1713 mL 15.8564 mL 31.7128 mL
5 mM 0.6343 mL 3.1713 mL 6.3426 mL
10 mM 0.3171 mL 1.5856 mL 3.1713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1713 mL 15.8564 mL 31.7128 mL 79.2820 mL
5 mM 0.6343 mL 3.1713 mL 6.3426 mL 15.8564 mL
10 mM 0.3171 mL 1.5856 mL 3.1713 mL 7.9282 mL
15 mM 0.2114 mL 1.0571 mL 2.1142 mL 5.2855 mL
20 mM 0.1586 mL 0.7928 mL 1.5856 mL 3.9641 mL
25 mM 0.1269 mL 0.6343 mL 1.2685 mL 3.1713 mL
30 mM 0.1057 mL 0.5285 mL 1.0571 mL 2.6427 mL
40 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
50 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5856 mL
60 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3214 mL
80 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
100 mM 0.0317 mL 0.1586 mL 0.3171 mL 0.7928 mL
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SM-360320 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-360320226907-52-4CL-087SM360320SM 360320CL087CL 087Toll-like Receptor (TLR)oralTLR7antitumor effectDNA vaccinesTh1Inhibitorinhibitorinhibit

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製品名:
SM-360320
製品番号:
HY-125390
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