1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. CL264

CL264 

Cat. No.: HY-135905
Handling Instructions

CL264 is a TLR7-specific agonist for innate immune signals research.

For research use only. We do not sell to patients.

CL264 Chemical Structure

CL264 Chemical Structure

CAS No. : 1510712-69-2

Size Price Stock Quantity
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

CL264 is a TLR7-specific agonist for innate immune signals research[1].

IC50 & Target[1]

TLR7

 

In Vitro

Toll like receptors (TLRs) are the best-studied class of receptors that are essential players in the detection of a range of lipid-, protein-, nucleic acid-based PAMPs. TLR7 is expressed predominantly in plasmacytoid dendritic cells (pDCs), macrophages and B cells. Many TLR7 modulators are interferon inducers, anti-cancer agents, anti-infectious agents, therapeutic agents for immunological diseases and vaccine adjuvants[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

413.43

Formula

C₁₉H₂₃N₇O₄

CAS No.
SMILES

O=C(O)CNC(C1=CC=C(CN2C(NC3=C(N)N=C(NCCCC)N=C23)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4188 mL 12.0939 mL 24.1879 mL
5 mM 0.4838 mL 2.4188 mL 4.8376 mL
10 mM 0.2419 mL 1.2094 mL 2.4188 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CL264CL 264CL-264Toll-like Receptor (TLR)TLR7specificinnateimmuneInhibitorinhibitorinhibit

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Product Name:
CL264
Cat. No.:
HY-135905
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