2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Smilaxchinoside A

Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia.

For research use only. We do not sell to patients.

Smilaxchinoside A

Smilaxchinoside A Chemical Structure

CAS No. : 935530-84-0

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Smilaxchinoside A Related Antibodies

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Description

Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia[1].

In Vivo

Smilaxchinoside A (10 mg/kg; p.o.; daily; 7 days) exerts significant antihyperuricemic and renoprotective effects in potassium oxonate-induced hyperuricemic mice by inhibiting XOD activity and down-regulating renal mURAT1 expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming (male, 20 ± 2.0 g, potassium oxonate-induced hyperuricemia)[1]
Dosage: 10 mg/kg
Administration: P.o.; daily; 7 days
Result: Significantly reduced serum uric acid levels and increased urine uric acid levels compared to the hyperuricemic model group.
Significantly decreased serum creatinine and serum BUN levels compared to the hyperuricemic model group.
Increased urine creatinine levels and the fractional excretion of uric acid compared to the hyperuricemic model group.
Significantly reduced serum and liver xanthine oxidase (XOD) activities compared to the hyperuricemic model group.
Significantly down-regulated renal mURAT1 protein expression compared to the hyperuricemic model group.
Showed no significant effects on renal mGLUT9 or mOAT1 protein levels compared to the hyperuricemic model group.
Molecular Weight

1047.18

Formula

C51H82O22
CAS No.
SMILES

C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@](O)(/C(O3)=C/C[C@H](C)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)=CC5)C)([H])CC1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Smilaxchinoside A Related Classifications

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Keywords:

Smilaxchinoside A935530-84-0Xanthine OxidaseXOXODxanthine oxidasemouse Urate Transporter 1mURAT1hyperuricemicrenal dysfunctionInhibitorinhibitorinhibit

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