Smilaxchinoside A
Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia.
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- CAS. Nr.: 935530-84-0
- Formel: C51H82O22
- Molecular Weight:1047.18
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming (male, 20 ± 2.0 g, potassium oxonate-induced hyperuricemia)[1]
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Dosage:10 mg/kg
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Administration:P.o.; daily; 7 days
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Result:Significantly reduced serum uric acid levels and increased urine uric acid levels compared to the hyperuricemic model group.
Significantly decreased serum creatinine and serum BUN levels compared to the hyperuricemic model group.
Increased urine creatinine levels and the fractional excretion of uric acid compared to the hyperuricemic model group.
Significantly reduced serum and liver xanthine oxidase (XOD) activities compared to the hyperuricemic model group.
Significantly down-regulated renal mURAT1 protein expression compared to the hyperuricemic model group.
Showed no significant effects on renal mGLUT9 or mOAT1 protein levels compared to the hyperuricemic model group.
Chemical Information
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CAS. Nr. 935530-84-0
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Molecular Weight 1047.18
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Formel C51H82O22
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SMILES
C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@](O)(/C(O3)=C/C[C@H](C)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)=CC5)C)([H])CC1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Smilaxchinoside A Related Classifications
HY-N17914 Related Classifications
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