2. Epigenetics Autophagy
  3. Histone Methyltransferase Autophagy
  4. SMYD3-IN-2

SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.

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SMYD3-IN-2

SMYD3-IN-2 構造式

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SMYD3-IN-2 関連抗体

Top Publications Citing Use of Products

Histone Methyltransferase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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製品説明

SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1].

IC50 & Target

SMYD3

0.81 μM μM (IC50)

Cellular Effect
Cell Line Type Value Description References
BGC-823 IC50
0.75 μM
Compound: 7r
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 36527933]
体外実験

SMYD3-IN-2 (compound 7r) (1.0 μM) exhibits potent inhibitory capacity against SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively[1].
SMYD3-IN-2 (1.0 μM; 24 h) can suppress Akt methylation and activation by SMYD3[1].
SMYD3-IN-2 (0-48 h) suppresses the proliferation of BGC823 stomach adenocarcinoma cells by inducing autophagic cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMYD3-IN-2 関連抗体

Western Blot Analysis[1]

Cell Line: BGC823 cells
Concentration: 1.0 μM
Incubation Time: 24 h
Result: Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.
体内実験

SMYD3-IN-2 (compound 7r) (i.p.; 15 and 30 mg/kg) suppresses the growth of BGC823 xenograft models in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xenograft Balb/c nude mice models[1]
Dosage: 15 and 30 mg/kg
Administration: Intraperitoneally administration
Result: Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner.
Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.
分子量

505.36

分子式

C26H21BrN2O4
SMILES

[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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SMYD3-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMYD3-IN-2Histone MethyltransferaseAutophagySMYD3programmed cell deathgastric cancerautophagyBGC823 cellInhibitorinhibitorinhibit

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製品番号:
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