Sodium 3-methyl-2-oxobutanoate-13C,d4-1
Sodium 3-methyl-2-oxobutanoate-13C,d4-1 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.
For research use only. We do not sell to patients.
- CAS No.: 2483824-45-7
- Formula: C413CH2D6NaO3
- Molecular Weight:146.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2483824-45-7
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Unlabeled CAS 3715-29-5
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Molecular Weight 146.13
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Formula C413CH2D6NaO3
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SMILES
[2H][13CH]([2H])C(C([2H])([2H])[2H])([2H])C(C(O)=O)=O.[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93. [Content Brief]
[3]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr103(4):597-605. [Content Brief]
[4]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9894(1):68-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sodium 3-methyl-2-oxobutanoate-13C,d4-1 Related Classifications
HY-W006057AS15 Related Classifications
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