SORT-PGRN interaction inhibitor 2
SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research.
For research use only. We do not sell to patients.
- CAS No.: 1008233-79-1
- Formula: C19H31NO
- Molecular Weight:289.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SORT-PGRN interaction inhibitor 2 (Compound MPEP) (0-20 μM; 24 hours) decreases SORT1 expression and increases extracellular PGRN secretion in mammalian cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:M17 cells, lymphoblastoid cell lines (LCLs) and iPSCs neurons, LCLs from two FTD-GRN families( UBC17 and UBC15)
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Concentration:0, 5, 10, 20 μM
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Incubation Time:24 h
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Result:Preferentially increased extracellular PGRN levels by suppressing or reducing intracellular SORT1 levels without affecting sortilin-related family members SORLA and SORCS1.
Made exPGRN levels in the heterozygous mutation carrier (GRN+/2-LCL) restored to a level comparable with the homozygous non-carrier (GRN+/+-LCL) in p.R418X mutation in family UBC17.
Made exPGRN levels in the UBC15 family restored to 80% of that of noncarrier GRN+/+-LCL levels.
Chemical Information
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CAS No. 1008233-79-1
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Molecular Weight 289.46
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Formula C19H31NO
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SMILES
CC1CN(CCOC2=CC(C)=CC=C2C(C)(C)C)CCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SORT-PGRN interaction inhibitor 2 Related Classifications
HY-153687 Related Classifications
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