TAB-004 

TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.^[1][2]

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

MUC1

TAB-004 (30 min) specifically binds to human tMUC1-expressing MMT murine breast cancer cells, with no detectable binding to tMUC1-negative PyMT murine breast cancer cells^[1].
TAB-004 (3 ng/ml) potently and specifically binds to the MUC1 peptide with detectable binding at 20 pM in a cell-free ELISA^[2].
TAB-004 specifically detects human MUC1 in human and murine pancreatic cancer cell lines (KCM, BxPC3.MUC1, HPAF-II) via Western blot, with no cross-reactivity to murine MUC1 in KCKO cells^[2].
TAB-004 specifically detects the expression of tMUC1 in BxPC3, PANC-1 and HPAF-II human pancreatic cancer cells by flow cytometry, and can recognize tMUC1 on the surface of more than 95% of Triple⁺ and CD133⁺ pancreatic cancer stem cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAB-004 (intratumoral; intravenous; intraperitoneal) specifically localizes to orthotopic MMT breast tumors in C57BL/6 mice, with the strongest tumor localization observed via intraperitoneal administration^[1].
TAB-004 (1:500-1:1000 dilution; 2-4 μg/mL) specifically detects human MUC1 on pancreatic cancer cells and > 95% of two distinct pancreatic cancer stem cell populations (CD133⁺ and Triple⁺) in athymic nude mouse tumor models, and accurately identifies shed MUC1 in serum from mice with MUC1 high tumors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4582  [NCBI]

P15941

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.97 kDa

Liquid

Colorless to light yellow

[TAB-004]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Immobilized Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc, HY-P78740) can bind TAB-004. The EC₅₀ for this effect is 24.88 ng/mL.

• [1]. Moore LJ, et al. Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors. Transl Oncol. 2016 Aug;9(4):295-305.  [Content Brief]

  [2]. Curry JM, et al. The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. J Surg Oncol. 2013;107(7):713-722.  [Content Brief]