TAB-004
Based on 1 Customer Validation
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.
For research use only. We do not sell to patients.
- Purity: 95.45%
- Molecular Weight:145.97 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Human IgG4 kappa
Human
MUC1
TAB-004 (30 min) specifically binds to human tMUC1-expressing MMT murine breast cancer cells, with no detectable binding to tMUC1-negative PyMT murine breast cancer cells[1].
TAB-004 (3 ng/ml) potently and specifically binds to the MUC1 peptide with detectable binding at 20 pM in a cell-free ELISA[2].
TAB-004 specifically detects human MUC1 in human and murine pancreatic cancer cell lines (KCM, BxPC3.MUC1, HPAF-II) via Western blot, with no cross-reactivity to murine MUC1 in KCKO cells[2].
TAB-004 specifically detects the expression of tMUC1 in BxPC3, PANC-1 and HPAF-II human pancreatic cancer cells by flow cytometry, and can recognize tMUC1 on the surface of more than 95% of Triple+ and CD133+ pancreatic cancer stem cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TAB-004 (1:500-1:1000 dilution; 2-4 μg/mL) specifically detects human MUC1 on pancreatic cancer cells and > 95% of two distinct pancreatic cancer stem cell populations (CD133+ and Triple+) in athymic nude mouse tumor models, and accurately identifies shed MUC1 in serum from mice with MUC1 high tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
-
Immobilized Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc, HY-P78740) can bind TAB-004. The EC50 for this effect is 24.88 ng/mL.
Chemical Information
-
Appearance Liquid
-
Molecular Weight 145.97 kDa
-
Color Colorless to light yellow
-
SMILES
[TAB-004]
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (260 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Moore LJ, et al. Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors. Transl Oncol. 2016 Aug;9(4):295-305. [Content Brief]
[2]. Curry JM, et al. The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. J Surg Oncol. 2013;107(7):713-722. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAB-004 Related Classifications
HY-P991319 Related Classifications
Powered by Bioz