1. Apoptosis
  2. Apoptosis
  3. Tasisulam sodium

Tasisulam sodium (Synonyms: LY 573636 sodium)

Cat. No.: HY-14804A
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Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.

For research use only. We do not sell to patients.

Tasisulam sodium Chemical Structure

Tasisulam sodium Chemical Structure

CAS No. : 519055-63-1

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Description

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1].

In Vitro

Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].
Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 nM-200 μM
Incubation Time: 48 hours
Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: Calu-6 and A-375 cell lines
Concentration: 25, 50 μM
Incubation Time: 72 hours
Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation.

Apoptosis Analysis[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 nM-200 μM
Incubation Time: 48 hours
Result: Induced apoptosis in a broad range of in vitro cancer cell models.
Clinical Trial
Molecular Weight

437.09

Formula

C₁₁H₅BrCl₂NNaO₃S₂

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Tasisulam sodium
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HY-14804A
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