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Cat. No.: HY-N1171

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Taxinine B

(Synonyms: Taxinin B)

Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl₂-induced depolymerization of microtubule. Taxinine B is useful for overcoming multidrug resistance in tumor cells.

For research use only. We do not sell to patients.

CAS No.: 18457-44-8
Formula: C₃₇H₄₄O₁₁
Molecular Weight:664.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Taxinine B Chemical Structure

CAS No.: 18457-44-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	3.9 μg/mL Compound: 11	Cytotoxic activity of compound was evaluated against KB cell line. Cytotoxic activity of compound was evaluated against KB cell line.	[PMID: 12217376]
KB	IC₅₀	>10 μg/mL Compound: 22	Cytotoxicity against human epidermoid carcinoma KB cells Cytotoxicity against human epidermoid carcinoma KB cells	10.1016/S0960-894X(97)00029-2
KB 3-1	ED₅₀	4.1 μg/mL Compound: 11	Cytotoxic activity of compound was evaluated against drug resistant subline KB-7d cells Cytotoxic activity of compound was evaluated against drug resistant subline KB-7d cells	[PMID: 12217376]
L1210	IC₅₀	>10 μg/mL Compound: 22	Cytotoxicity against murine leukemia L1210 cells Cytotoxicity against murine leukemia L1210 cells	10.1016/S0960-894X(97)00029-2

Chemical Information

CAS No. 18457-44-8
Molecular Weight 664.74
Formula C₃₇H₄₄O₁₁
SMILES

O=C(O[C@H](C1=C)C[C@H](OC(C)=O)[C@]([C@@H](OC(C)=O)[C@H](OC(C)=O)C2=C3C)(C)[C@]1([H])[C@H](OC(C)=O)[C@](C2(C)C)([H])CC3=O)/C=C/C4=CC=CC=C4
Synonyms

Taxinin B
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Juníchi Kobayashi, et al. Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron. 1994. 50 (25), 7401-7416.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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