Tozorakimab
Based on 2 publication(s) in Google Scholar
Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease.
For research use only. We do not sell to patients.
- Purity : 98.82%
- CAS No.: 2376858-66-9
- Molecular Weight:144.66 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Tozorakimab
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Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IL-33
In Vivo
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 lambda
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human IL-33 Protein can bind Tozorakimab. The EC50 for this effect is 3.21 ng/mL. -
Flow cytometric analysis of 1.5×106 HUVEC cells with Tozorakimab (HY-P99550, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control.
Chemical Information
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CAS No. 2376858-66-9
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Appearance Liquid
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Molecular Weight 144.66 kDa
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Color Colorless to light yellow
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SMILES
[Tozorakimab]
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Synonyms
MEDI-3506
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression. [Abstract]2026 Jun 8;44(6):1179-1200.e14. PMID: 41997138 -
Environ Int
Polystyrene particles induces asthma-like Th2-mediated lung injury through IL-33 secretion. [Abstract]2025 Sep:203:109772. PMID: 40926454
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)