Trehalose 6,6′-dimycolate
Based on 1 publication(s) in Google Scholar
Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 61512-20-7
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Trehalose 6,6′-dimycolate
More
Biological Activity
Administration: 0.5 or 1.25 mg/kg • i.v., or i.p. first then i.v. • once
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female C57BL/6 mice (6-8 weeks, 20 g)[1]
-
Dosage:0.5, 1.25 mg/kg (10 μg, 25 μg per 20 g mice)
-
Administration:Intravenous injection (i.v.) once (0.5, 1.25 mg/kg), or received 0.5 mg/kg via Intraperitoneal injection (i.p.) followed by an i.v. after 7 days of 0.5 mg/kg
-
Result:Increased the lung weight index (LWI). Local aggregation of macrophages was observed 7 days later at 0.5 mg/kg. The size and number of granulomas increased, inflammation intensified, alveolar spaces decreased, small hemorrhagic petechiae appeared, and lymphocytes mainly infiltrated at the intersection of granulomas and blood vessels at 1.25 mg/kg. In i.p.+i.v. model, the inflammatory response was more aggressive. Induced vascular remodeling and collagen deposition.
Chemical Information
-
CAS No. 61512-20-7
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Trehalose 6,6?dimycolate]
-
Synonyms
Cord Factor
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Adv Sci (Weinh)
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis. [Abstract]2026 Jun;13(33):e20635. PMID: 41933939
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hwang SA, et al. Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation. Tuberculosis (Edinb). 2019 May;116S:S118-S122. [Content Brief]
[2]. Welsh KJ, et al. Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb). 2013 Dec;93 Suppl:S3-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trehalose 6,6′-dimycolate Related Classifications
HY-W145657 Related Classifications
Powered by Bioz