TRK-IN-29
TRK-IN-29 (Compound B31) is a second-generation TRK inhibitor (IC50: 9 nM, 0.6 nM, 18 nM, 5 nM, 6 nM for TRKAG595R, TRKAF589L, TRKAG667C, TRKA and TRKC respectively). TRK-IN-29 inhibits the phosphorylation of TRKA. TRK-IN-29 has good antiproliferative activities against NTRK fusion positive cells. TRK-IN-29 has exellent plasma stability and moderate pharmacokinetic properties.
For research use only. We do not sell to patients.
- Formula: C19H17F3N6O
- Molecular Weight:402.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
4.7 nM
Compound: B31
|
Antiproliferative activity against mouse BaF3 cells expressing TRKA G595R mutant incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells expressing TRKA G595R mutant incubated for 72 hrs by CCK8 assay
|
[PMID: 39033612] |
| BaF3 | IC50 |
9.9 nM
Compound: B31
|
Antiproliferative activity against mouse BaF3 cells expressing TRKA G667C mutant incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells expressing TRKA G667C mutant incubated for 72 hrs by CCK8 assay
|
[PMID: 39033612] |
| KM12 | IC50 |
0.3 nM
Compound: B31
|
Antiproliferative activity against human KM12 cells incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human KM12 cells incubated for 72 hrs by CCK8 assay
|
[PMID: 39033612] |
| MCF7 | IC50 |
1150 nM
Compound: B31
|
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
|
[PMID: 39033612] |
TRK-IN-29 shows strong antiproliferative activities against Km-12, Ba/F3-TRKAG595R, and Ba/F3-TRKAG667C cell lines with IC50 values of 0.3, 4.7, and 9.9 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 402.37
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Formula C19H17F3N6O
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SMILES
C[C@H](C1=CC(F)=CC=C1OCC(F)F)NC2=CC3=C(NN=C3N4N=CN=C4)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)