TrkB-IN-2
TrkB-IN-2 is a TrkB inhibitor. TrkB-IN-2 exhibits anticancer activity against neuroblastoma. TrkB-IN-2 can be used for research on neuroblastoma.
For research use only. We do not sell to patients.
- Formula: C24H21FN4O6S
- Molecular Weight:512.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TrkB |
In Vitro
TrkB-IN-2 (500 nM; 30 min) is among the most effective compounds at suppressing BDNF-induced TrkB phosphorylation in ECP007 cells[1].
TrkB-IN-2 (100-10000 nM; 30 min) effectively suppresses BDNF-induced TrkB phosphorylation in ECP007 cells in a dose-dependent manner[1].
TrkB-IN-2 (0.005-100 μM; 72 h) inhibits the growth of COG-N-549 neuroblastoma cells and exhibits cytostatic effects on CUTO-3 cells at concentrations under 10,000 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ECP007
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Concentration:500 nM
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Incubation Time:30 min
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Result:Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.
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Cell Line:ECP007
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Concentration:100-10000 nM
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Incubation Time:30 min
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Result:Showed the greatest decrease in the ratio of phosphorylated TrkB to total TrkB.
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Cell Line:COG-N-549, ECP005, ECP007, CUTO-3
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Concentration:0.005-100 μM
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Incubation Time:72 h
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Result:Showed growth inhibition in COG-N-549 cells.
Showed cytostatic growth inhibition in CUTO-3 cells at concentrations under 10,000 nM.
Chemical Information
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Molecular Weight 512.51
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Formula C24H21FN4O6S
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SMILES
COC1=CC(C2=NN=C(N2C3=CC=CC=C3)S(=O)(CC(NC4=CC(F)=CC=C4OC)=O)=O)=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrkB-IN-2 Related Classifications
HY-189255 Related Classifications
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