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Cat. No.: HY-151398

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Tubulin polymerization-IN-37

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC₅₀: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas.

For research use only. We do not sell to patients.

CAS No.: 2011784-92-0
Formula: C₁₉H₂₀N₂O₄
Molecular Weight:340.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tubulin polymerization-IN-37 Chemical Structure

CAS No.: 2011784-92-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Tubulin polymerization^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	0.99 μM Compound: 6k	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
HBL1	IC₅₀	0.08 μM Compound: 2f	Antiproliferative activity against human HBL1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HBL1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 36242921]
M14	IC₅₀	0.89 μM Compound: 6k	Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
MCF-10A	IC₅₀	>100 μM Compound: 6k	Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
MCF7	IC₅₀	0.21 μM Compound: 2f	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition Cytotoxicity against human MCF7 cells assessed as cell growth inhibition	[PMID: 36242921]
MCF7	IC₅₀	0.92 μM Compound: 6k	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
MDA-MB-231	IC₅₀	0.75 μM Compound: 6k	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
PC-3	IC₅₀	0.87 μM Compound: 6k	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]
SU-DHL10	IC₅₀	0.07 μM Compound: 2f	Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 36242921]
WI-38	IC₅₀	>100 μM Compound: 6k	Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 27643641]

In Vitro

Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%^[1].
Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells^[1].
Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80%^[1].
Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC₅₀: 0.21 μΜ)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

VL51, MINO, HBL1, SU-DHL-10 cells.
Concentration:

0-10 μΜ
Incubation Time:

72 h
Result:

Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively. IC₅₀s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively.

Cell Cycle Analysis^[1]

Cell Line:

VL51 and MINO cells
Concentration:

50 and 500 nM
Incubation Time:

24, 48 and 72 h
Result:

Arrested cell in G2/M phase.

Chemical Information

CAS No. 2011784-92-0
Molecular Weight 340.37
Formula C₁₉H₂₀N₂O₄
SMILES

COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49(3): 1165-81. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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