1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin polymerization-IN-37

Tubulin polymerization-IN-37 

Cat. No.: HY-151398
Handling Instructions

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-37 Chemical Structure

Tubulin polymerization-IN-37 Chemical Structure

CAS No. : 2011784-92-0

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Description

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].

IC50 & Target

Tubulin polymerization[1]

In Vitro

Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1].
Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1].
Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80%[1].
Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC50: 0.21 μΜ)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells.
Concentration: 0-10 μΜ
Incubation Time: 72 h
Result: Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively. IC50s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively.

Cell Cycle Analysis[1]

Cell Line: VL51 and MINO cells
Concentration: 50 and 500 nM
Incubation Time: 24, 48 and 72 h
Result: Arrested cell in G2/M phase.
Molecular Weight

340.37

Formula

C19H20N2O4

CAS No.
SMILES

COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Tubulin polymerization-IN-37
Cat. No.:
HY-151398
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