HNRNPAB - heterogeneous nuclear ribonucleoprotein A/B Gene

Also Known as ABBP1; HNRPAB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3182

About HNRNPAB

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,204,533-178,211,163 (from NCBI)

This gene has 8 transcripts (splice variants), 286 orthologues and 36 paralogues. Ubiquitous expression in colon (RPKM 79.0), appendix (RPKM 50.6) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

HNRNPAB Products (2)

mRNA	Protein	Name
NM_004499.4	NP_004490.2	heterogeneous nuclear ribonucleoprotein A/B isoform b
NM_031266.3	NP_112556.2	heterogeneous nuclear ribonucleoprotein A/B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12692135	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA modification	IDA IDA: Inferred from direct assay	11134005	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	12881431	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12881431	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPAB Protein Structure

CBFNT

RRM_1

0
100
200
300
332 a.a.

Protein Preferred Names	Protein Names
heterogeneous nuclear ribonucleoprotein A/B	ABBP-1

HNRNPAB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HNRNPAB	Q99729	TP63	Homo sapiens	Q9H3D4	Y2H	12692135
Intra	HNRNPAB	Q99729	TP63	Homo sapiens	Q9H3D4-1	Pull Down	12692135
Intra	HNRNPAB	Q99729	TP63	Homo sapiens	Q9H3D4-2	Anti Bait CoIP	12692135
Intra	HNRNPAB	Q99729	TP63	Homo sapiens	Q9H3D4-2	Pull Down	12692135
Intra	HNRNPAB	Q99729	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate	Hay-Wells Syndrome Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome Aec Syndrome AEC Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome Seres-Santamaria Arimany Muniz Syndrome Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects Ankyloblepharon Ectodermal Defects Cleft Lip/Palate Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate Rapp-Hodgkin Syndrome
Dihydropyrimidine Dehydrogenase Deficiency	Dpd Deficiency Familial Pyrimidinemia Hereditary Thymine-Uraciluria Dihydropyrimidinuria Dpyd Deficiency Thymine-Uraciluria, Hereditary Pyrimidinemia, Familial 5-Fluorouracil Toxicity Dihydrouracil Dehydrogenase Deficiency Familial Pyrimidinaemia Thymine-Uracilurea Familial Pyrimidemia Pyrimidinemia Familial DPYDD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06264	HNRNPAB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HNRNPAB	RGD	RGD:69255
Bos taurus	HNRNPAB	VGNC	VGNC:52241
Canis familiaris	HNRNPAB	VGNC	VGNC:56067
Mus musculus	HNRNPAB	MGD	MGI:1330294
Macaca mulatta	HNRNPAB	VGNC	VGNC:73495
Felis catus	HNRNPAB	VGNC	VGNC:102225
Others	HNRNPAB	NCBI