MAP3K10 - mitogen-activated protein kinase kinase kinase 10 Gene

Also Known as MST; MLK2; MEKK10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4294

About MAP3K10

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,191,426-40,215,575 (from NCBI)

This gene has 8 transcripts (splice variants), 186 orthologues and 23 paralogues. Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal Apoptosis. [provided by RefSeq, Jul 2008]

MAP3K10 Products (1)

mRNA	Protein	Name
NM_002446.4	NP_002437.2	mitogen-activated protein kinase kinase kinase 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	19801649	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19801649	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19801649	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19801649	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19801649	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	19801649	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	17584736	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	17584736	GOA
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18455992	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18455992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K10 Protein Structure

SH3_9

Pkinase_Tyr

0
200
400
600
800
954 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 10	MKN28 derived nonreceptor_type serine/threonine kinase

MAP3K10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAP3K10	Q02779	MAP3K21	Homo sapiens	Q5TCX8	Pull Down	32707033

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175809	SRT6	Inhibitor	/	Unkown
HY-RS08047	MAP3K10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP3K10	VGNC	VGNC:68154
Mus musculus	MAP3K10	MGD	MGI:1346879
Macaca mulatta	MAP3K10	VGNC	VGNC:74492
Bos taurus	MAP3K10	VGNC	VGNC:57052
Rattus norvegicus	MAP3K10	RGD	RGD:1308381
Canis familiaris	MAP3K10	VGNC	VGNC:53748
Others	MAP3K10	NCBI