CAMLG - calcium modulating ligand Gene

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to Cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate Calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to Cyclophilin B and acting downstream of the TCR and upstream of Calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating Cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]