KIO-301
KIO-301 is a photosensitizer with selective retinal ganglion cell uptake properties. KIO-301 acts on HCN channels and endogenous voltage-gated cation channels, thereby enabling photoswitch-mediated photoresponses and light-driven action potential generation. KIO-301 confers rapid and reliable light-evoked spike responses in retinal explants from mouse models of retinal degeneration, producing sustained light-evoked responses. KIO-301 can be used in research related to retinal degeneration.
For research use only. We do not sell to patients.
- CAS No.: 1643463-61-9
- Formula: C29H38BrN5O
- Molecular Weight:552.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
KIO‑301 enters RGCs through the P2X7 large-pore channel highly expressed in degenerated retinas, non-covalently binds to the intracellular domain of HCN channels, and relies on light-controlled reversible isomerization to regulate HCN channel opening and closing and modulate Na+ influx, thereby controlling RGC depolarization and action potential firing[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1643463-61-9
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Molecular Weight 552.55
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Formula C29H38BrN5O
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SMILES
O=C(C[N+](CC)(CC)CC)NC1=CC=C(C=C1)/N=N/C2=CC=C(N(CC)CC3=CC=CC=C3)C=C2.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KIO-301 Related Classifications
HY-160209 Related Classifications
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Keywords
- KIO-301
- 1643463-61-9
- KIO301
- KIO 301
- Photosensitizer
- HCN Channel
- Hyperpolarization activated cyclic nucleotide gated channels
- HCN channels
- light-driven action potential generation
- light-evoked spiking responses
- mouse model
- photoswitch-mediated light responses
- retinal degeneration
- retinal explants
- retinal ganglion cell uptake
- retinitis pigmentosa
- voltage-gated cation channels
- Inhibitor
- inhibitor
- inhibit