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Cat. No.: HY-P11889

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Tyrocidine A

Tyrocidine A is an amphipathic cyclic decapeptide natural product, as well as a membrane-disrupting agent and an antibacterial agent. Tyrocidine A exhibits moderate activity against Gram-positive bacteria. Tyrocidine A can insert into bacterial cell membranes, form porous channels, disrupt membrane integrity and induce bacterial cell death. Tyrocidine A can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1481-70-5
Formula: C₆₆H₈₇N₁₃O₁₃
Molecular Weight:1270.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrocidine A Chemical Structure

CAS No.: 1481-70-5

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Tyrocidine A (overnight treatment) exhibits moderate antibacterial activity against Gram-positive strains (MIC 16-32 μg/mL) at a calcium ion concentration of 25 mg/L, while it shows no activity against Gram-negative E. coli ATCC 25922 (MIC >128 μg/mL); its activity decreases moderately at a calcium ion concentration of 50 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1481-70-5
Molecular Weight 1270.48
Formula C₆₆H₈₇N₁₃O₁₃
SMILES

O=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1CC3=CC=CC=C3)=O)CC(C)C)=O)CCCN)=O)C(C)C)=O)CC4=CC=C(C=C4)O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O
Sequence

cyclo(Asn-Gln-Tyr-Val-Orn-Leu-DPhe-Pro-Phe-DPhe)
Sequence Shortening

cyclo(NQYV-Orn-L-DPhe-PF-DPhe)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marques MA, et al.. Development of Tyrocidine A analogues with improved antibacterial activity. Bioorganic & medicinal chemistry. 2007 Nov 01;15(21):6667-77. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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