Tyrocidine A TFA
Based on 1 Customer Validation
Tyrocidine A TFA is an amphipathic cyclic decapeptide natural product, as well as a membrane-disrupting agent and an antibacterial agent. Tyrocidine A TFA exhibits moderate activity against Gram-positive bacteria. Tyrocidine A TFA can insert into bacterial cell membranes, form porous channels, disrupt membrane integrity and induce bacterial cell death. Tyrocidine A TFA can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- Formula: C66H87N13O13·xC2HF3O2
- Molecular Weight:1270.48 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tyrocidine A TFA (overnight treatment) exhibits moderate antibacterial activity against Gram-positive strains (MIC 16-32 μg/mL) at a calcium ion concentration of 25 mg/L, while it shows no activity against Gram-negative E. coli ATCC 25922 (MIC >128 μg/mL); its activity decreases moderately at a calcium ion concentration of 50 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1270.48 (free base)
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Formula C66H87N13O13·xC2HF3O2
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SMILES
O=C(O)C(F)(F)F.O=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1CC3=CC=CC=C3)=O)CC(C)C)=O)CCCN)=O)C(C)C)=O)CC4=CC=C(C=C4)O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O.[x]
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Sequence
cyclo(Asn-Gln-Tyr-Val-Orn-Leu-DPhe-Pro-Phe-DPhe)
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Sequence Shortening
cyclo(NQYV-Orn-L-DPhe-PF-DPhe)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyrocidine A TFA Related Classifications
HY-P11889A Related Classifications
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