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Cat. No.: HY-W736050

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D-Cysteic acid

D-Cysteic acid is a competitive inhibitor of the aspartate:alanine antiporter (AspT) from Tetragenococcus halophilus. For L-aspartate self-exchange, D-Cysteic acid has a K_i of 0.14 mM and an IC₅₀ of 0.19 mM; for L-alanine self-exchange, it has a K_i of 5.0 mM and an IC₅₀ of 9.0 mM. D-Cysteic acid occupies a distinct substrate-binding site within the substrate transport pathway of AspT, preventing the binding of natural substrates to the transporter. D-Cysteic acid can be used in studies related to substrate recognition and transport mechanisms of transporters.

For research use only. We do not sell to patients.

CAS No.: 35554-98-4
Formula: C₃H₇NO₅S
Molecular Weight:169.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-Cysteic acid Chemical Structure

CAS No.: 35554-98-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

D-cysteic acid competitively inhibits L-aspartate and L-alanine self-exchange via reconstituted Tetragenococcus halophilus AspT, with greater potency against L-aspartate self-exchange (K_i = 0.14 mM; IC₅₀ = 0.19 mM) than L-alanine self-exchange (K_i = 5.0 mM; IC₅₀=9.0 mM)^[1].
D-Cysteic acid is formed via oxidation of L-cysteine with performic acid at 50°C for 15 min^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 35554-98-4
Molecular Weight 169.15
Formula C₃H₇NO₅S
SMILES

[C@@H](CS(=O)(=O)O)(C(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sasahara A, et al. Substrate specificity of the aspartate:alanine antiporter (AspT) of Tetragenococcus halophilus in reconstituted liposomes. J Biol Chem. 2011;286(33):29044-29052. [Content Brief]

[2]. Varga-Visi E, et al. RPHPLC determination of L- and D-cystine and cysteine as cysteic acid. Chromatographia. 2012 Apr;51(1):S325-S327.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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